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Dr Mohammed Rohaim

Senior Research Associate

Furness Building

LA1 4YG

Lancaster

Research overview

My primary focus revolves around comprehending the innate immune responses across various hosts, spanning from virus detection to the terminal interferon-mediated effects facilitated by an array of interferon-stimulated and virus-regulated genes. Utilizing expansive, genome-wide, and high-throughput screening platforms, my research aims to elucidate the distinct host reactions to various viral pathogens and grasp the underlying factors influencing genetic resistance or susceptibility across different species. This involves investigating virus-host cell interactions, particularly the mechanisms by which both viral and cellular components modulate the viral replication cycle and counteract the innate immune response. Additionally, through the application of genome-wide transcriptomics and proteomics methodologies, my work delves into unraveling the molecular determinants of viral pathogenesis and elucidating how viruses, such as influenza and coronaviruses, have evolved to evade the host's innate immunity. Another aspect of my research involves exploring the evolution of RNA viruses and delineating the functional significance of evolutionary alterations in terms of virus antigenicity, virulence, transmission dynamics, and host range expansion. Furthermore, I strive to enhance vaccine development and vaccination strategies for effective virus control, as well as to develop reagents and assays for rapid detection and differentiation of virus subtypes.

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