My focus is to understand the innate immune responses in different hosts that range from sensing of viruses to terminal IFN effectors mediated by myriad of interferon-stimulated and virus-regulated genes. Employing large-scale, genome-wide and high-throughput screening platforms, my research is deciphering differential host responses to diverse viral pathogens and understanding the bases for genetic resistance/susceptibility of different avian species, virus-host cell interaction, especially how viral and cellular factors regulate the viral replication cycle; live cell imaging and viral replication compartments; virus assembly and involved host cell factors; mathematical modelling of virus replication and the race with the innate immune response; mechanism of viral RNA recognition by pattern recognition receptors; interferon response and viral counter measures; antiviral therapy and mode-of-action of selected antiviral compounds. Additionally, applying genome-wide transcriptomics and proteomics approaches, my research is trying to understand molecular determinants of viral pathogenesis (infection) and the ways viruses (e.g. influenza viruses and SARS-CoV2) have adapted to avoid innate immune responses in hosts. Likewise, other research focus is to investigating influenza and SARS-CoV2 viruses evolution and defining the functional role of evolutionary changes on virus antigenicity, virulence, transmission and host-range, improving vaccines and vaccination strategies for effective control of virus infection and developing reagents and assays for rapid detection and differentiation of virus subtypes.