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Research

Professor Thomas Jaki

Formerly at Lancaster University

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  1. Published

    Statistical approaches for the determination of cut points in anti-drug antibody bioassays

    Schaarschmidt, F., Hofmann, M., Jaki, T., Gruen, B. & Hothorn, L. A., 03/2015, In: Journal of Immunological Methods. 418, p. 84-100 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    A novel measure of drug benefit–risk assessment based on Scale Loss Score

    Saint-Hilary, G., Robert, V., Gasparini, M., Jaki, T. F. & Mozgunov, P., 1/09/2019, In: Statistical Methods in Medical Research. 28, 9, p. 2738-2753 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Point estimation for adaptive trial designs I: A methodological review

    Robertson, D. S., Choodari‐Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. & Jaki, T., 30/01/2023, In: Statistics in Medicine. 42, 2, p. 122-145 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. E-pub ahead of print

    Proposing a Core Outcome Set for Physical Activity and Exercise Interventions in People With Rare Neurological Conditions

    Ramdharry, G., Buscemi, V., Boaz, A., Dawes, H., Jaki, T., Jones, F., Marsden, J., Paul, L., Playle, R., Randell, E., Robling, M., Rochester, L. & Busse, M., 21/10/2021, (E-pub ahead of print) In: Frontiers in Rehabilitation Sciences. 2, 13 p., 705474.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy

    Pushpakom, S. P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcıa-Finana, M., Kemp, G. J., Whitehead, J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/10/2015, In: BMJ Open. 5, 10, 13 p., e009566.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy

    Pushpakom, S., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., García-Fiñana, M., Kemp, G. J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/05/2020, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 10, p. 2062-2072 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Multiplicity: discussion points from the PSI multiplicity expert group

    Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P., 09/2013, In: Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Simultaneous confidence regions for multivariate bioequivalence

    Pallmann, P. S. & Jaki, T. F., 20/12/2017, In: Statistics in Medicine. 36, 29, p. 4585-4603 19 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Designing and evaluating dose-escalation studies made easy: The MoDEsT web app

    Pallmann, P., Wan, F., Mander, A. P., Wheeler, G. M., Yap, C., Clive, S., Hampson, L. V. & Jaki, T., 1/04/2020, In: Clinical Trials. 17, 2, p. 147-156 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    A review of the deterministic and diffusion approximations for stochastic chemical reaction networks

    Mozgunov, P., Beccuti, M., Horvath, A., Jaki, T. F., Sirovich, R. & Bibbona, E., 04/2018, In: Reaction Kinetics, Mechanisms and Catalysis. 123, 2, p. 289-312 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. E-pub ahead of print

    An information-theoretic Phase I/II design for molecularly targeted agents that does not require an assumption of monotonicity

    Mozgunov, P. & Jaki, T. F., 15/06/2018, (E-pub ahead of print) In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 68, 2, p. 347-367 21 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    A benchmark for dose finding studies with continuous outcomes

    Mozgunov, P., Jaki, T. F. & Paoletti, X., 1/04/2020, In: Biostatistics. 21, 2, p. 189–201 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. E-pub ahead of print

    Randomized dose-escalation designs for drug combination cancer trials with immunotherapy

    Mozgunov, P., Jaki, T. F. & Paoletti, X., 23/10/2018, (E-pub ahead of print) In: Journal of Biopharmaceutical Statistics. 29, 2, p. 359-377 19 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Loss Functions in Restricted Parameter Spaces and Their Bayesian Applications

    Mozgunov, P., Jaki, T. F. & Gasparini, M., 3/10/2019, In: Journal of Applied Statistics. 46, 13, p. 2314-2337 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    An information-theoretic approach for selecting arms in clinical trials

    Mozgunov, P. & Jaki, T. F., 10/11/2020, In: Journal of the Royal Statistical Society: Series B (Statistical Methodology). 82, 5, p. 1223-1247 25 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    A flexible design for advanced Phase I/II clinical trials with continuous efficacy endpoints

    Mozgunov, P. & Jaki, T., 1/11/2019, In: Biometrical Journal. 61, 6, p. 1477-1492 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Improving safety of the continual reassessment method via a modified allocation rule

    Mozgunov, P. & Jaki, T., 30/03/2020, In: Statistics in Medicine. 39, 7, p. 906-922 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    A surface-free design for phase I dual-agent combination trials

    Mozgunov, P., Gasparini, M. & Jaki, T., 1/10/2020, In: Statistical Methods in Medical Research. 29, 10, p. 3093-3109 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Using a Dose-Finding Benchmark to Quantify the Loss Incurred by Dichotomisation in Phase II Dose-Ranging Studies

    Mozgunov, P., Jaki, T. & Paoletti, X., 1/11/2020, In: Biometrical Journal. 62, 7, p. 1717-1729 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Using a dose-finding benchmark to quantify the loss incurred by dichotomization in Phase II dose-ranging studies

    Mozgunov, P., Jaki, T. & Paoletti, X., 1/11/2020, In: Biometrical Journal. 62, 7, p. 1717-1729 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    A Benchmark for Dose Finding Studies with Unknown Ordering

    Mozgunov, P., Paoletti, X. & Jaki, T., 31/07/2022, In: Biostatistics. 23, 3, p. 721-737 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study

    Mozgunov, P., Knight, R., Barnett, H. & Jaki, T., 5/01/2021, In: International Journal of Environmental Research and Public Health. 18, 1, 19 p., 345.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial

    Mozgunov, P., Cro, S., Lingford-Hughes, A., Paterson, L. M. & Jaki, T., 31/03/2022, In: Pharmaceutical Statistics. 21, 2, p. 476-495 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial

    Mozgunov, P., Jaki, T., Gounaris, I., Goddemeier, T., Victor, A. & Grinberg, M., 30/12/2022, In: Stat. Med.. 41, 30, p. 5789-5809 21 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis

    McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., Smyth, A. R., Smyth, R. L. & Pirmohamed, M., 4/02/2020, In: Scientific Reports. 10, 1, 9 p., 1796.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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