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Research

Professor Thomas Jaki

Formerly at Lancaster University

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  1. Published

    Using a Dose-Finding Benchmark to Quantify the Loss Incurred by Dichotomisation in Phase II Dose-Ranging Studies

    Mozgunov, P., Jaki, T. & Paoletti, X., 1/11/2020, In: Biometrical Journal. 62, 7, p. 1717-1729 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Using a dose-finding benchmark to quantify the loss incurred by dichotomization in Phase II dose-ranging studies

    Mozgunov, P., Jaki, T. & Paoletti, X., 1/11/2020, In: Biometrical Journal. 62, 7, p. 1717-1729 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    A Benchmark for Dose Finding Studies with Unknown Ordering

    Mozgunov, P., Paoletti, X. & Jaki, T., 31/07/2022, In: Biostatistics. 23, 3, p. 721-737 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study

    Mozgunov, P., Knight, R., Barnett, H. & Jaki, T., 5/01/2021, In: International Journal of Environmental Research and Public Health. 18, 1, 19 p., 345.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial

    Mozgunov, P., Cro, S., Lingford-Hughes, A., Paterson, L. M. & Jaki, T., 31/03/2022, In: Pharmaceutical Statistics. 21, 2, p. 476-495 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Practical implementation of the partial ordering continual reassessment method in a Phase I combination‐schedule dose‐finding trial

    Mozgunov, P., Jaki, T., Gounaris, I., Goddemeier, T., Victor, A. & Grinberg, M., 30/12/2022, In: Stat. Med.. 41, 30, p. 5789-5809 21 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Simultaneous confidence regions for multivariate bioequivalence

    Pallmann, P. S. & Jaki, T. F., 20/12/2017, In: Statistics in Medicine. 36, 29, p. 4585-4603 19 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Designing and evaluating dose-escalation studies made easy: The MoDEsT web app

    Pallmann, P., Wan, F., Mander, A. P., Wheeler, G. M., Yap, C., Clive, S., Hampson, L. V. & Jaki, T., 1/04/2020, In: Clinical Trials. 17, 2, p. 147-156 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Multiplicity: discussion points from the PSI multiplicity expert group

    Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P., 09/2013, In: Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of Telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy

    Pushpakom, S. P., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcıa-Finana, M., Kemp, G. J., Whitehead, J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/10/2015, In: BMJ Open. 5, 10, 13 p., e009566.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy

    Pushpakom, S., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., García-Fiñana, M., Kemp, G. J., Jaki, T., Khoo, S., Williamson, P. & Pirmohamed, M., 15/05/2020, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 10, p. 2062-2072 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. E-pub ahead of print

    Proposing a Core Outcome Set for Physical Activity and Exercise Interventions in People With Rare Neurological Conditions

    Ramdharry, G., Buscemi, V., Boaz, A., Dawes, H., Jaki, T., Jones, F., Marsden, J., Paul, L., Playle, R., Randell, E., Robling, M., Rochester, L. & Busse, M., 21/10/2021, (E-pub ahead of print) In: Frontiers in Rehabilitation Sciences. 2, 13 p., 705474.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Point estimation for adaptive trial designs I: A methodological review

    Robertson, D. S., Choodari‐Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. & Jaki, T., 30/01/2023, In: Statistics in Medicine. 42, 2, p. 122-145 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    A novel measure of drug benefit–risk assessment based on Scale Loss Score

    Saint-Hilary, G., Robert, V., Gasparini, M., Jaki, T. F. & Mozgunov, P., 1/09/2019, In: Statistical Methods in Medical Research. 28, 9, p. 2738-2753 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Statistical approaches for the determination of cut points in anti-drug antibody bioassays

    Schaarschmidt, F., Hofmann, M., Jaki, T., Gruen, B. & Hothorn, L. A., 03/2015, In: Journal of Immunological Methods. 418, p. 84-100 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Toward Accelerated Authorization and Access to New Medicines for Juvenile Idiopathic Arthritis

    Schanberg, L. E., Ramanan, A. V., De Benedetti, F., Beukelman, T., Eakin, G. S., Del Gaizo, V., Ringold, S., Vesely, R., Schrandt, S., Jaki, T., Bili, A., Chung, J. B., De Bono, S., Douglass, W., Enejosa, J. V., Kanik, K. S., Knobe, K., Kunder, R., Leite-Schnell, J. C., Suehiro, R. M., & 6 othersWong, R. L., Mieszkalski, K. L., Marrow, L. C., Siebenaler, K., Fraulo, E. & Kimura, Y., 1/12/2019, In: Arthritis and Rheumatology. 71, 12, p. 1976-1984 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    An order restricted multi-arm multi-stage clinical trial design

    Serra, A., Mozgunov, P. & Jaki, T., 30/04/2022, In: Statistics in Medicine. 41, 9, p. 1613-1626 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    What is the expected benefit of patient-centric clinical development in oncology?

    Serra, A., Mozgunov, P., Jaki, T. & Rigat, F., 31/07/2022, In: Journal of Biopharmaceutical Statistics. 32, 3, p. 414-426 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    A Bayesian multi‐arm multi‐stage clinical trial design incorporating information about treatment ordering

    Serra, A., Mozgunov, P. & Jaki, T., 20/07/2023, In: Statistics in Medicine. 42, 16, p. 2841-2854 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study

    Solovyeva, O., Dimairo, M., Weir, C. J., Hee, S. W., Espinasse, A., Ursino, M., Patel, D., Kightley, A., Hughes, S., Jaki, T., Mander, A., Evans, T. R. J., Lee, S., Hopewell, S., Rantell, K. R., Chan, A-W., Bedding, A., Stephens, R., Richards, D., Roberts, L., & 3 othersKirkpatrick, J., de Bono, J. & Yap, C., 5/07/2023, In: BMC Medicine. 21, 1, 246.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Probabilistic relabelling strategies for the label switching problem in Bayesian mixture models.

    Sperrin, M., Jaki, T. & Wit, E., 07/2010, In: Statistics and Computing. 20, 3, p. 357-366 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Direct effects testing : a two-stage procedure to test for effect size and variable importance for correlated binary predictors and a binary response.

    Sperrin, M. & Jaki, T., 30/10/2010, In: Statistics in Medicine. 29, 24, p. 2544-2556 13 p.

    Research output: Contribution to Journal/Magazine › Journal article

  23. Published

    Recovering Independent Associations in Genetics: A Comparison

    Sperrin, M. & Jaki, T., 08/2012, In: Journal of Computational Biology. 19, 8, p. 978–987 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19

    Stallard, N., Hampson, L., Benda, N., Brannath, W., Burnett, T., Friede, T., Kimani, P. K., Koenig, F., Krisam, J., Mozgunov, P., Posch, M., Wason, J., Wassmer, G., Whitehead, J., Williamson, S. F., Zohar, S. & Jaki, T., 1/10/2020, In: Statistics in Biopharmaceutical Research. 12, 4, p. 483-497 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    A review of statistical updating methods for clinical prediction models

    Su, T-L., Jaki, T. F., Hickey, G., Buchan, I. & Sperrin, M., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 185-197 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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