Planning multi-arm screening studies within the context of a drug development programme

Wason, J., Jaki, T. & Stallard, N., 10/09/2013, In: Statistics in Medicine. 32, 20, p. 3424-3435 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Performance of different clinical trial designs to evaluate treatments during an epidemic

Brueckner, M., Titman, A. C., Jaki, T. F., Rojek, A. & Horby, P. W., 11/09/2018, In: PLoS ONE. 13, 9, 19 p., e0203387.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimizing subgroup selection in two-stage adaptive enrichment and umbrella designs

Ballarini, N. M., Burnett, T., Jaki, T., Jennison, C., König, F. & Posch, M., 31/05/2021, In: Statistics in Medicine. 40, 12, p. 2939-2956 18 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.

Baumgartner, B., Jaki, T., Wolfsegger, M. J., Eder, B., Schiviz, A., Schwarz, H. P. & Muchitsch, E. M., 07/2010, In: Laboratory Animals. 44, 3, p. 211-217 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

Khoo, S. H., Fitzgerald, R., Fletcher, T., Ewings, S., Jaki, T., Lyon, R., Downs, N., Walker, L., Tansley-Hancock, O., Greenhalf, W., Woods, C., Reynolds, H., Marwood, E., Mozgunov, P., Adams, E., Bullock, K., Holman, W., Bula, M. D., Gibney, J. L., Saunders, G., & 18 othersCorkhill, A., Hale, C., Thorne, K., Chiong, J., Condie, S., Pertinez, H., Painter, W., Wrixon, E., Johnson, L., Yeats, S., Mallard, K., Radford, M., Fines, K., Shaw, V., Owen, A., Lalloo, D. G., Jacobs, M. & Griffiths, G., 12/11/2021, In: Journal of Antimicrobial Chemotherapy. 76, 12, p. 3286-3295 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimal Designs for Non-Compartmental Analysis of Pharmacokinetic Studies

Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T. F., 2018, In: Statistics in Biopharmaceutical Research. 10, 4, p. 255-263 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimal design of multi-arm multi-stage trials

Wason, J. & Jaki, T., 30/12/2012, In: Statistics in Medicine. 31, 30, p. 4269-4279 11 p.

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One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

Whitehead, J. & Jaki, T., 28/02/2009, In: Statistics in Medicine. 28, 5, p. 828-847 20 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Not quite normal: Consequences of violating the assumption of normality with regression mixture models

Van Horn, M. L., Smith, J., Fagan, A., Jaki, T., Maysn, K., Hawkins, D., Feaster, D. & Howe, G., 2012, In: Structural Equation Modeling. 19, 2, p. 227-249 23 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.

Wolfsegger, M. J. & Jaki, T., 10/2009, In: Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

Jaki, T. & Wolfsegger, M. J., 2012, In: Statistics in Medicine. 31, 11-12, p. 1059-1073 25 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Multiplicity: discussion points from the PSI multiplicity expert group

Phillips, A., Fletcher, C., Atkinson, G., Channon, E., Douiri, A., Jaki, T., Maca, J., Morgan, D., Roger, J. H. & Terrill, P., 09/2013, In: Pharmaceutical Statistics. 12, 5, p. 255-259 5 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke: a case study

Jaki, T. & Wason, J. M. S., 27/11/2018, In: BMC Cardiovascular Disorders. 18, 1, 8 p., 215.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Multi-arm clinical trials with treatment selection: what can be gained and at what price?

Jaki, T., 04/2015, In: Clinical Investigation. 5, 4, p. 393-399 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Modeling predictors of latent classes in regression mixture models

Kim, M., Vermunt, J., Bakk, Z., Jaki, T. F. & Van Horn, M. L., 06/2016, In: Structural Equation Modeling. 23, 4, p. 601-614 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Model-Based dose escalation Designs in R with crmPack

Bové, D. S., Yeung, W. Y., Palermo, G. & Jaki, T., 13/06/2019, In: Journal of Statistical Software. 89, 10, 22 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Model selection based on combined penalties for biomarker identification

Vradi, E., Brannath, W., Jaki, T. & Vonk, R., 4/07/2018, In: Journal of Biopharmaceutical Statistics. 28, 4, p. 735-749 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Methods for Non-Compartmental Pharmacokinetic Analysis With Observations Below the Limit of Quantification

Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T., 2/01/2021, In: Statistics in Biopharmaceutical Research. 13, 1, p. 59-70 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials”: a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing

Law, M., Couturier, D-L., Choodari-Oskooei, B., Crout, P., Gamble, C., Jacko, P., Pallmann, P., Pilling, M., Robertson, DS., Robling, M., Sydes, MR., Villar, SS., Wason, J., Wheeler, G., Williamson, S. F., Yap, C. & Jaki, T., 5/10/2023, In: Trials. 24, 1

Research output: Contribution to Journal/Magazine › Letter › peer-review

Maximum kernel likelihood estimation

Jaki, T. & West, R. W., 2008, In: Journal of Computational and Graphical Statistics. 17, 4, p. 976-993 18 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Loss Functions in Restricted Parameter Spaces and Their Bayesian Applications

Mozgunov, P., Jaki, T. F. & Gasparini, M., 3/10/2019, In: Journal of Applied Statistics. 46, 13, p. 2314-2337 24 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Instrumental variable estimation in semi-parametric additive hazards models

Brueckner, M., Titman, A. C. & Jaki, T. F., 1/03/2019, In: Biometrics. 75, 1, p. 110-120 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity

Kuhlemeier, A., Jaki, T., Jimenez, E. Y., Kong, A. S., Gill, H., Chang, C., Resnicow, K., Wilson, D. K. & Van Horn, M. L., 30/04/2022, In: Journal of Behavioral Medicine. 45, 2, p. 211-226 16 p.

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Improving safety of the continual reassessment method via a modified allocation rule

Mozgunov, P. & Jaki, T., 30/03/2020, In: Statistics in Medicine. 39, 7, p. 906-922 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Impact of an equality constraint on the class-specific residual variances in regression mixtures: a Monte Carlo simulation study

Kim, M., Lamont, A. E., Jaki, T., Feaster, D., Howe, G. & Van Horn, M. L., 06/2016, In: Behavior Research Methods. 48, 2, p. 813-826 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review