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Martínez-Planas, A, Baquero-Artigao, F, Méndez-Echevarría, A, Del Rosal, T, Rodríguez-Molino, P, Toro-Rueda, C, Bustillo-Alonso, M, Lafuente, M, Canet, A, Manzanares, Á, Tagarro, A, Sanz-Santaeufemia, FJ, Guillén-Martín, S, Cilleruelo, MJ, Falcón-Neyra, L, Santiago, B, Rincón, E, Lillo, M, Soriano-Arandes, A
, Sedda, L, Fortuny, C, Monsonís, M, González-Martín, J, Tebruegge, M, Noguera-Julian, A, Gutiérrez-Abad, C, Gavilán, C, Valmanya, T, Minguell-Domingo, L, Mellado, MJ, Álvarez, J, Villalobos-Pinto, E, Pérez-Gorricho, B, Rodríguez, S, Torres, D, Blázquez-Gamero, D, Prieto, L, Ruiz, B, Santos, M, Hernández-Sanpelayo, T, Blanco, IR, Roa, M, Gómez, AB, Morales, A, Rueda, S, Galé, I, Guerrero-Laleona, C, Terraza, SM, Viñuelas, J, Álvarez, R, Ruiz, M, Calvo, JC, Neth, O, Cepillo, A, Martín-Nalda, A, Espiau, M, Soler-Palacín, P, Moreno, D, Núñez, E, Menasalvas-Ruiz, A, Martinón-Torres, F, Dacosta-Urbieta, A, Calavia, O, Lahoz, R, Murua, JJK, Alonso, M, Arroyo, M, Pomar, I, Herrero, S, Pérez-Tamarit, A, Piqueras, A, Otero, C, Carreras, M, Álvarez, C, Lobato, Z, Garcia, L, Rius, N, Guarch, B, Couceiro, J & van Ingen, J 2025, '
A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain',
Emerging Infectious Diseases, vol. 31, no. 3, pp. 536-546.
https://doi.org/10.3201/eid3103.241254APA
Martínez-Planas, A., Baquero-Artigao, F., Méndez-Echevarría, A., Del Rosal, T., Rodríguez-Molino, P., Toro-Rueda, C., Bustillo-Alonso, M., Lafuente, M., Canet, A., Manzanares, Á., Tagarro, A., Sanz-Santaeufemia, F. J., Guillén-Martín, S., Cilleruelo, M. J., Falcón-Neyra, L., Santiago, B., Rincón, E., Lillo, M., Soriano-Arandes, A., ... van Ingen, J. (2025).
A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain.
Emerging Infectious Diseases,
31(3), 536-546.
https://doi.org/10.3201/eid3103.241254Vancouver
Author
Bibtex
@article{7a41c85993bf4403a790d0af4df726eb,
title = "A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain",
abstract = "We describe the epidemiology, diagnosis, and management of nontuberculous mycobacterial lymphadenitis cases detailed in a 28-year (1996–2023) multicenter cohort from Spain. The case numbers remained stable during the initial prospective phase (2013–2020), but a sharp decline was observed during 2021–2022. Disease onset occurred during spring or June in 45.9% of cases. Mycobacterium avium complex (43.1%) and M. lentiflavum (39.9%) were the most common species detected. M. lentiflavum affected mostly younger children from central Spain. The most common treatment strategy was complete surgical resection with (n = 80) or without (n = 88) antimicrobial drug treatment, followed by antimicrobial drugs alone (n = 76). Facial palsy developed in 10.4% of surgical cases. Adverse events because of antimicrobial drugs were uncommon. New fistula formation during follow-up occurred more in children managed with observation alone than in those treated with antimicrobial drugs alone (relative risk 2.7 [95% CI 1.3–5.3]; p = 0.014).",
author = "A. Mart{\'i}nez-Planas and F. Baquero-Artigao and A. M{\'e}ndez-Echevarr{\'i}a and {Del Rosal}, T. and P. Rodr{\'i}guez-Molino and C. Toro-Rueda and M. Bustillo-Alonso and M. Lafuente and A. Canet and {\'A}. Manzanares and A. Tagarro and F.J. Sanz-Santaeufemia and S. Guill{\'e}n-Mart{\'i}n and M.J. Cilleruelo and L. Falc{\'o}n-Neyra and B. Santiago and E. Rinc{\'o}n and M. Lillo and A. Soriano-Arandes and L. Sedda and C. Fortuny and M. Monson{\'i}s and J. Gonz{\'a}lez-Mart{\'i}n and M. Tebruegge and A. Noguera-Julian and C. Guti{\'e}rrez-Abad and C. Gavil{\'a}n and T. Valmanya and L. Minguell-Domingo and M.J. Mellado and J. {\'A}lvarez and E. Villalobos-Pinto and B. P{\'e}rez-Gorricho and S. Rodr{\'i}guez and D. Torres and D. Bl{\'a}zquez-Gamero and L. Prieto and B. Ruiz and M. Santos and T. Hern{\'a}ndez-Sanpelayo and I.R. Blanco and M. Roa and A.B. G{\'o}mez and A. Morales and S. Rueda and I. Gal{\'e} and C. Guerrero-Laleona and S.M. Terraza and J. Vi{\~n}uelas and R. {\'A}lvarez and M. Ruiz and J.C. Calvo and O. Neth and A. Cepillo and A. Mart{\'i}n-Nalda and M. Espiau and P. Soler-Palac{\'i}n and D. Moreno and E. N{\'u}{\~n}ez and A. Menasalvas-Ruiz and F. Martin{\'o}n-Torres and A. Dacosta-Urbieta and O. Calavia and R. Lahoz and J.J.K. Murua and M. Alonso and M. Arroyo and I. Pomar and S. Herrero and A. P{\'e}rez-Tamarit and A. Piqueras and C. Otero and M. Carreras and C. {\'A}lvarez and Z. Lobato and L. Garcia and N. Rius and B. Guarch and J. Couceiro and {van Ingen}, J.",
year = "2025",
month = mar,
day = "31",
doi = "10.3201/eid3103.241254",
language = "English",
volume = "31",
pages = "536--546",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "3",
}
RIS
TY - JOUR
T1 - A 28-Year Multicenter Cohort Study of Nontuberculous Mycobacterial Lymphadenitis in Children, Spain
AU - Martínez-Planas, A.
AU - Baquero-Artigao, F.
AU - Méndez-Echevarría, A.
AU - Del Rosal, T.
AU - Rodríguez-Molino, P.
AU - Toro-Rueda, C.
AU - Bustillo-Alonso, M.
AU - Lafuente, M.
AU - Canet, A.
AU - Manzanares, Á.
AU - Tagarro, A.
AU - Sanz-Santaeufemia, F.J.
AU - Guillén-Martín, S.
AU - Cilleruelo, M.J.
AU - Falcón-Neyra, L.
AU - Santiago, B.
AU - Rincón, E.
AU - Lillo, M.
AU - Soriano-Arandes, A.
AU - Sedda, L.
AU - Fortuny, C.
AU - Monsonís, M.
AU - González-Martín, J.
AU - Tebruegge, M.
AU - Noguera-Julian, A.
AU - Gutiérrez-Abad, C.
AU - Gavilán, C.
AU - Valmanya, T.
AU - Minguell-Domingo, L.
AU - Mellado, M.J.
AU - Álvarez, J.
AU - Villalobos-Pinto, E.
AU - Pérez-Gorricho, B.
AU - Rodríguez, S.
AU - Torres, D.
AU - Blázquez-Gamero, D.
AU - Prieto, L.
AU - Ruiz, B.
AU - Santos, M.
AU - Hernández-Sanpelayo, T.
AU - Blanco, I.R.
AU - Roa, M.
AU - Gómez, A.B.
AU - Morales, A.
AU - Rueda, S.
AU - Galé, I.
AU - Guerrero-Laleona, C.
AU - Terraza, S.M.
AU - Viñuelas, J.
AU - Álvarez, R.
AU - Ruiz, M.
AU - Calvo, J.C.
AU - Neth, O.
AU - Cepillo, A.
AU - Martín-Nalda, A.
AU - Espiau, M.
AU - Soler-Palacín, P.
AU - Moreno, D.
AU - Núñez, E.
AU - Menasalvas-Ruiz, A.
AU - Martinón-Torres, F.
AU - Dacosta-Urbieta, A.
AU - Calavia, O.
AU - Lahoz, R.
AU - Murua, J.J.K.
AU - Alonso, M.
AU - Arroyo, M.
AU - Pomar, I.
AU - Herrero, S.
AU - Pérez-Tamarit, A.
AU - Piqueras, A.
AU - Otero, C.
AU - Carreras, M.
AU - Álvarez, C.
AU - Lobato, Z.
AU - Garcia, L.
AU - Rius, N.
AU - Guarch, B.
AU - Couceiro, J.
AU - van Ingen, J.
PY - 2025/3/31
Y1 - 2025/3/31
N2 - We describe the epidemiology, diagnosis, and management of nontuberculous mycobacterial lymphadenitis cases detailed in a 28-year (1996–2023) multicenter cohort from Spain. The case numbers remained stable during the initial prospective phase (2013–2020), but a sharp decline was observed during 2021–2022. Disease onset occurred during spring or June in 45.9% of cases. Mycobacterium avium complex (43.1%) and M. lentiflavum (39.9%) were the most common species detected. M. lentiflavum affected mostly younger children from central Spain. The most common treatment strategy was complete surgical resection with (n = 80) or without (n = 88) antimicrobial drug treatment, followed by antimicrobial drugs alone (n = 76). Facial palsy developed in 10.4% of surgical cases. Adverse events because of antimicrobial drugs were uncommon. New fistula formation during follow-up occurred more in children managed with observation alone than in those treated with antimicrobial drugs alone (relative risk 2.7 [95% CI 1.3–5.3]; p = 0.014).
AB - We describe the epidemiology, diagnosis, and management of nontuberculous mycobacterial lymphadenitis cases detailed in a 28-year (1996–2023) multicenter cohort from Spain. The case numbers remained stable during the initial prospective phase (2013–2020), but a sharp decline was observed during 2021–2022. Disease onset occurred during spring or June in 45.9% of cases. Mycobacterium avium complex (43.1%) and M. lentiflavum (39.9%) were the most common species detected. M. lentiflavum affected mostly younger children from central Spain. The most common treatment strategy was complete surgical resection with (n = 80) or without (n = 88) antimicrobial drug treatment, followed by antimicrobial drugs alone (n = 76). Facial palsy developed in 10.4% of surgical cases. Adverse events because of antimicrobial drugs were uncommon. New fistula formation during follow-up occurred more in children managed with observation alone than in those treated with antimicrobial drugs alone (relative risk 2.7 [95% CI 1.3–5.3]; p = 0.014).
U2 - 10.3201/eid3103.241254
DO - 10.3201/eid3103.241254
M3 - Journal article
VL - 31
SP - 536
EP - 546
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 3
ER -
