This thesis examines how open innovation is related to dynamic capabilities and strategic agility using an empirical approach. By adopting a microfoundations lens and examining open innovation processes, first, I develop a model to explain how open innovation is related to sensing and seizing abilities of the dynamic capability framework. Next, by considering resource bundling and individuals’ activities alongside broader organisational conditions and activities, I develop a framework to further explain the relationship between open innovation and a firm’s dynamic capability. Finally, to address the omission of speed from the dynamic capability literature and the development of resources and capabilities, I develop a framework to explain the interplay between open innovation and a firm’s strategic agility. In doing so, this thesis advances our understanding of the open innovation concept by linking open innovation to strategic firm-level concepts. Furthermore, this thesis contributes to our understanding of the multi-level nature of open innovation by uncovering microfoundations that underlie the relationship between open innovation and strategic firm-level concepts.