Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia
AU - Sri, S.
AU - Greenstein, A.
AU - Granata, A.
AU - Collcutt, A.
AU - Jochems, A.C.C.
AU - McColl, B.W.
AU - Castro, B.D.
AU - Webber, C.
AU - Reyes, C.A.
AU - Hall, C.
AU - Lawrence, C.B.
AU - Hawkes, C.
AU - Pegasiou-Davies, C.-M.
AU - Gibson, C.
AU - Crawford, C.L.
AU - Smith, C.
AU - Vivien, D.
AU - McLean, F.H.
AU - Wiseman, F.
AU - Brezzo, G.
AU - Lalli, G.
AU - Pritchard, H.A.T.
AU - Markus, H.S.
AU - Bravo-Ferrer, I.
AU - Taylor, J.
AU - Leiper, J.
AU - Berwick, J.
AU - Gan, J.
AU - Gallacher, J.
AU - Moss, J.
AU - Goense, J.
AU - McMullan, L.
AU - Work, L.
AU - Evans, L.
AU - Stringer, M.S.
AU - Ashford, M.L.J.
AU - Abulfadl, M.
AU - Conlon, N.
AU - Malhotra, P.
AU - Bath, P.
AU - Canter, R.
AU - Brown, R.
AU - Ince, S.
AU - Anderle, S.
AU - Young, S.
AU - Quick, S.
AU - Szymkowiak, S.
AU - Hill, S.
AU - Allan, S.
AU - Wang, T.
AU - Quinn, T.
AU - Procter, T.
AU - Farr, T.D.
AU - Zhao, X.
AU - Yang, Z.
AU - Hainsworth, A.H.
AU - Wardlaw, J.M.
N1 - Export Date: 9 November 2023
PY - 2023/12/31
Y1 - 2023/12/31
N2 - Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.
AB - Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.
KW - Vascular cognitive impairment
KW - Vascular dementia
KW - Small vessel disease
KW - Cerebral vascular disease
KW - Dementia
U2 - 10.1016/j.cccb.2023.100189
DO - 10.1016/j.cccb.2023.100189
M3 - Journal article
VL - 5
JO - Cerebral Circulation - Cognition and Behavior
JF - Cerebral Circulation - Cognition and Behavior
M1 - 100189
ER -