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A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds

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A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds. / Capozzi, Luigi C.; Barresi, Antonello A.; Pisano, Roberto.
In: Powder Technology, Vol. 343, 01.02.2019, p. 834-846.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Capozzi, LC, Barresi, AA & Pisano, R 2019, 'A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds', Powder Technology, vol. 343, pp. 834-846. https://doi.org/10.1016/j.powtec.2018.11.067

APA

Capozzi, L. C., Barresi, A. A., & Pisano, R. (2019). A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds. Powder Technology, 343, 834-846. https://doi.org/10.1016/j.powtec.2018.11.067

Vancouver

Capozzi LC, Barresi AA, Pisano R. A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds. Powder Technology. 2019 Feb 1;343:834-846. doi: 10.1016/j.powtec.2018.11.067

Author

Capozzi, Luigi C. ; Barresi, Antonello A. ; Pisano, Roberto. / A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds. In: Powder Technology. 2019 ; Vol. 343. pp. 834-846.

Bibtex

@article{dd2a0bd799be4ca181c8e318060e18da,
title = "A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds",
abstract = "This work investigates the behavior during freeze-drying of packing structures formed by spray-frozen microparticles. A multi-scale approach is used to study spray freeze-drying, and in particular, mass transfer during primary drying and its duration. The procedure starts with the generation of realistic packings of microparticles using DEM, and CFD simulations are used to determine some relevant characteristics at pore scale, i.e., porosity, tortuosity, the average size of the particle-to-particle voids, and permeability. Finally, these parameters are used to describe mass transfer within the packed-bed. This procedure is used to describe some actual case studies and evaluate drying time and mass transfer resistance within the packing. We also investigated the role of packing structure on freeze-drying by generating packings from monodisperse and Gaussian-polydisperse microparticles, demonstrating that polydispersity increased the mass transfer resistance, and, finally, drying time.",
keywords = "Freeze-Drying, Lyophilization, Packed-bed",
author = "Capozzi, {Luigi C.} and Barresi, {Antonello A.} and Roberto Pisano",
year = "2019",
month = feb,
day = "1",
doi = "10.1016/j.powtec.2018.11.067",
language = "English",
volume = "343",
pages = "834--846",
journal = "Powder Technology",
issn = "0032-5910",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A multi-scale computational framework for modeling the freeze-drying of microparticles in packed-beds

AU - Capozzi, Luigi C.

AU - Barresi, Antonello A.

AU - Pisano, Roberto

PY - 2019/2/1

Y1 - 2019/2/1

N2 - This work investigates the behavior during freeze-drying of packing structures formed by spray-frozen microparticles. A multi-scale approach is used to study spray freeze-drying, and in particular, mass transfer during primary drying and its duration. The procedure starts with the generation of realistic packings of microparticles using DEM, and CFD simulations are used to determine some relevant characteristics at pore scale, i.e., porosity, tortuosity, the average size of the particle-to-particle voids, and permeability. Finally, these parameters are used to describe mass transfer within the packed-bed. This procedure is used to describe some actual case studies and evaluate drying time and mass transfer resistance within the packing. We also investigated the role of packing structure on freeze-drying by generating packings from monodisperse and Gaussian-polydisperse microparticles, demonstrating that polydispersity increased the mass transfer resistance, and, finally, drying time.

AB - This work investigates the behavior during freeze-drying of packing structures formed by spray-frozen microparticles. A multi-scale approach is used to study spray freeze-drying, and in particular, mass transfer during primary drying and its duration. The procedure starts with the generation of realistic packings of microparticles using DEM, and CFD simulations are used to determine some relevant characteristics at pore scale, i.e., porosity, tortuosity, the average size of the particle-to-particle voids, and permeability. Finally, these parameters are used to describe mass transfer within the packed-bed. This procedure is used to describe some actual case studies and evaluate drying time and mass transfer resistance within the packing. We also investigated the role of packing structure on freeze-drying by generating packings from monodisperse and Gaussian-polydisperse microparticles, demonstrating that polydispersity increased the mass transfer resistance, and, finally, drying time.

KW - Freeze-Drying

KW - Lyophilization

KW - Packed-bed

U2 - 10.1016/j.powtec.2018.11.067

DO - 10.1016/j.powtec.2018.11.067

M3 - Journal article

AN - SCOPUS:85057738492

VL - 343

SP - 834

EP - 846

JO - Powder Technology

JF - Powder Technology

SN - 0032-5910

ER -