Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - A note on change point estimation in dose-response trials.
AU - Friede, T.
AU - Miller, F.
AU - Bischoff, W.
AU - Kieser, M.
PY - 2001
Y1 - 2001
N2 - An often used model for the shape of a drug's dose–response relationship is the following: the curve increases to a certain dose until a plateau is reached. In this situation, the minimum dose with maximum effect can be seen as a change point in a regression model. We present four estimators for the change point and compare their performance with respect to selection rates and loss function based criteria by extensive simulations. The choice of the loss function depending on the practical situation is discussed. Application of the estimators is illustrated by an example.
AB - An often used model for the shape of a drug's dose–response relationship is the following: the curve increases to a certain dose until a plateau is reached. In this situation, the minimum dose with maximum effect can be seen as a change point in a regression model. We present four estimators for the change point and compare their performance with respect to selection rates and loss function based criteria by extensive simulations. The choice of the loss function depending on the practical situation is discussed. Application of the estimators is illustrated by an example.
KW - Change point estimator
KW - Dose–response relationship
KW - Loss function
KW - LINEX loss
U2 - 10.1016/S0167-9473(00)00066-9
DO - 10.1016/S0167-9473(00)00066-9
M3 - Journal article
VL - 37
SP - 219
EP - 232
JO - Computational Statistics and Data Analysis
JF - Computational Statistics and Data Analysis
IS - 2
ER -