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A tool to assess the quality of a meta-analysis

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Julian P. T. Higgins
  • Peter W. Lane
  • Betsy Anagnostelis
  • Judith Anzures-Cabrera
  • Nigel F. Baker
  • Joseph C. Cappelleri
  • Scott Haughie
  • Sally Hollis
  • Steff C. Lewis
  • Patrick Moneuse
  • Anne Whitehead
<mark>Journal publication date</mark>12/2013
<mark>Journal</mark>Research Synthesis Methods
Issue number4
Number of pages16
Pages (from-to)351-366
Publication StatusPublished
<mark>Original language</mark>English


Background: Because meta-analyses are increasingly prevalent and cited in the medical literature, it is important that tools are available to assess their methodological quality. When performing an empirical study of the quality of published meta-analyses, we found that existing tools did not place a strong
emphasis on statistical and interpretational issues.
Methods: We developed a quality-assessment tool using existing materials and expert judgment as a starting point, followed by multiple iterations of input from our working group, piloting, and discussion. After having used the tool for our empirical study, agreement for four key items in the tool was measured
using weighted kappa coefficients.
Results: Our tool contained 43 items divided into four key areas (data sources, analysis of individual studies, meta-analysis methods, and interpretation), and each area ended with a summary question. We also produced guidance for completing the tool. Agreement between raters was fair to moderate.
Conclusions: The tool should usefully inform subsequent initiatives to develop quality-assessment tools for meta-analysis. We advocate use of consensus between independent raters when assessing statistical appropriateness and adequacy of interpretation in meta-analyses.