Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - A versatile sample injection system for miniaturised isotachophoresis devices
AU - Baldock, S. J.
AU - Fielden, P. R.
AU - Goddard, N. J.
AU - Kretschmer, H. R.
AU - Prest, J. E.
AU - Brown, B. J. Treves
PY - 2008/5
Y1 - 2008/5
N2 - A variable-volume sample injector design is presented and evaluated for performing sample introduction protocols for carrying out miniaturised isotachophoresis (ITP) separations. The microdevice design features a wide bore sample loop channel connected to a narrower bore separation channel via a short injection channel angled at 45°. An additional side arm channel located at the injection point enabled a range of injection strategies, using a gravity-fed system, to be implemented and assessed. A model analyte was used to demonstrate the versatility of the injector design for low and high sample loading regimes suitable for concentrated and dilute sample solutions, respectively.
AB - A variable-volume sample injector design is presented and evaluated for performing sample introduction protocols for carrying out miniaturised isotachophoresis (ITP) separations. The microdevice design features a wide bore sample loop channel connected to a narrower bore separation channel via a short injection channel angled at 45°. An additional side arm channel located at the injection point enabled a range of injection strategies, using a gravity-fed system, to be implemented and assessed. A model analyte was used to demonstrate the versatility of the injector design for low and high sample loading regimes suitable for concentrated and dilute sample solutions, respectively.
KW - Isotachophoresis
KW - Electroseparation
KW - Miniaturisation
KW - Injection methods
KW - Instrumentation
KW - Chip technologies
KW - Microfluidic
U2 - 10.1016/j.mee.2008.01.095
DO - 10.1016/j.mee.2008.01.095
M3 - Journal article
VL - 85
SP - 1440
EP - 1442
JO - Microelectronic Engineering
JF - Microelectronic Engineering
SN - 0167-9317
IS - 5-6
ER -