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Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle.

Research output: Contribution to journalJournal articlepeer-review

  • A. K. Masters
  • H. Huddart
  • A. M. Hetherington
<mark>Journal publication date</mark>05/1994
<mark>Journal</mark>General Pharmacology
Issue number3
Number of pages6
Pages (from-to)481-486
Publication StatusPublished
<mark>Original language</mark>English


1. 1. K+-induced and Ca2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca2+ modulatory activity. 2. 2. The Ca2+ agonist BAY K8644 significantly enhanced Ca2+-induced contractures while the Ca2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca2+ concentration range employed. 3. 3. At 10−7 mol 1−1 ABA had no significant effect on K+-induced or Ca2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations. 4. 4. The ABA analogue SD217595 strongly inhibited Ca2+-induced contractures over the whole Ca2+ concentration range employed in both prostatic and epididymal vas deferens. 5. 5. It is concluded that ABA is without significant Ca2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca2+ entry blocking ability.