Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle.
AU - Masters, A. K.
AU - Huddart, H.
AU - Hetherington, A. M.
PY - 1994/5
Y1 - 1994/5
N2 - 1. 1. K+-induced and Ca2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca2+ modulatory activity. 2. 2. The Ca2+ agonist BAY K8644 significantly enhanced Ca2+-induced contractures while the Ca2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca2+ concentration range employed. 3. 3. At 10−7 mol 1−1 ABA had no significant effect on K+-induced or Ca2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations. 4. 4. The ABA analogue SD217595 strongly inhibited Ca2+-induced contractures over the whole Ca2+ concentration range employed in both prostatic and epididymal vas deferens. 5. 5. It is concluded that ABA is without significant Ca2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca2+ entry blocking ability.
AB - 1. 1. K+-induced and Ca2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca2+ modulatory activity. 2. 2. The Ca2+ agonist BAY K8644 significantly enhanced Ca2+-induced contractures while the Ca2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca2+ concentration range employed. 3. 3. At 10−7 mol 1−1 ABA had no significant effect on K+-induced or Ca2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations. 4. 4. The ABA analogue SD217595 strongly inhibited Ca2+-induced contractures over the whole Ca2+ concentration range employed in both prostatic and epididymal vas deferens. 5. 5. It is concluded that ABA is without significant Ca2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca2+ entry blocking ability.
KW - Abscisic acic
KW - BAY K8644
KW - calcium contractures
KW - K-depolarization
KW - nifedipine
U2 - 10.1016/0306-3623(94)90202-X
DO - 10.1016/0306-3623(94)90202-X
M3 - Journal article
VL - 25
SP - 481
EP - 486
JO - General Pharmacology
JF - General Pharmacology
IS - 3
ER -