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Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle.

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Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle. / Masters, A. K.; Huddart, H.; Hetherington, A. M.
In: General Pharmacology, Vol. 25, No. 3, 05.1994, p. 481-486.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Masters, AK, Huddart, H & Hetherington, AM 1994, 'Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle.', General Pharmacology, vol. 25, no. 3, pp. 481-486. https://doi.org/10.1016/0306-3623(94)90202-X

APA

Masters, A. K., Huddart, H., & Hetherington, A. M. (1994). Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle. General Pharmacology, 25(3), 481-486. https://doi.org/10.1016/0306-3623(94)90202-X

Vancouver

Masters AK, Huddart H, Hetherington AM. Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle. General Pharmacology. 1994 May;25(3):481-486. doi: 10.1016/0306-3623(94)90202-X

Author

Masters, A. K. ; Huddart, H. ; Hetherington, A. M. / Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle. In: General Pharmacology. 1994 ; Vol. 25, No. 3. pp. 481-486.

Bibtex

@article{6a3f241847614caeac2851545a80aacb,
title = "Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle.",
abstract = "1. 1. K+-induced and Ca2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca2+ modulatory activity. 2. 2. The Ca2+ agonist BAY K8644 significantly enhanced Ca2+-induced contractures while the Ca2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca2+ concentration range employed. 3. 3. At 10−7 mol 1−1 ABA had no significant effect on K+-induced or Ca2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations. 4. 4. The ABA analogue SD217595 strongly inhibited Ca2+-induced contractures over the whole Ca2+ concentration range employed in both prostatic and epididymal vas deferens. 5. 5. It is concluded that ABA is without significant Ca2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca2+ entry blocking ability.",
keywords = "Abscisic acic, BAY K8644, calcium contractures, K-depolarization, nifedipine",
author = "Masters, {A. K.} and H. Huddart and Hetherington, {A. M.}",
year = "1994",
month = may,
doi = "10.1016/0306-3623(94)90202-X",
language = "English",
volume = "25",
pages = "481--486",
journal = "General Pharmacology",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - Actions of abscisic acid and the analogue SD217595 on calcium mediated activity of rat vas deferens smooth muscle.

AU - Masters, A. K.

AU - Huddart, H.

AU - Hetherington, A. M.

PY - 1994/5

Y1 - 1994/5

N2 - 1. 1. K+-induced and Ca2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca2+ modulatory activity. 2. 2. The Ca2+ agonist BAY K8644 significantly enhanced Ca2+-induced contractures while the Ca2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca2+ concentration range employed. 3. 3. At 10−7 mol 1−1 ABA had no significant effect on K+-induced or Ca2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations. 4. 4. The ABA analogue SD217595 strongly inhibited Ca2+-induced contractures over the whole Ca2+ concentration range employed in both prostatic and epididymal vas deferens. 5. 5. It is concluded that ABA is without significant Ca2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca2+ entry blocking ability.

AB - 1. 1. K+-induced and Ca2+-induced contractures of rat prostatic and epididymal vas deferens smooth muscle were used to screen ABA and its analogue SD217595 for Ca2+ modulatory activity. 2. 2. The Ca2+ agonist BAY K8644 significantly enhanced Ca2+-induced contractures while the Ca2+ entry blocker nifedipine strongly inhibited such contractures in both types of vas deferens preparation over the whole Ca2+ concentration range employed. 3. 3. At 10−7 mol 1−1 ABA had no significant effect on K+-induced or Ca2+-induced contractures nor did it change the phasic/tonic force ratio in the preparations. 4. 4. The ABA analogue SD217595 strongly inhibited Ca2+-induced contractures over the whole Ca2+ concentration range employed in both prostatic and epididymal vas deferens. 5. 5. It is concluded that ABA is without significant Ca2+ modulatory activity in this smooth muscle preparation but the ABA analogue SD217595 possesses strong Ca2+ entry blocking ability.

KW - Abscisic acic

KW - BAY K8644

KW - calcium contractures

KW - K-depolarization

KW - nifedipine

U2 - 10.1016/0306-3623(94)90202-X

DO - 10.1016/0306-3623(94)90202-X

M3 - Journal article

VL - 25

SP - 481

EP - 486

JO - General Pharmacology

JF - General Pharmacology

IS - 3

ER -