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Alcohol consumption and cognitive performance: a Mendelian randomization study

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Alcohol consumption and cognitive performance : a Mendelian randomization study. / Kumari, Meena; Holmes, Michael V.; Dale, Caroline E.; Hubacek, Jaroslav A.; Palmer, Tom M.; Pikhart, Hynek; Peasey, Anne; Britton, Annie; Horvat, Pia; Kubinova, Ruzena; Malyutina, Sofia; Pajak, Andrzej; Tamosiunas, Abdonas; Shankar, Aparna; Singh-Manoux, Archana; Voevoda, Mikhail; Kivimaki, Mika; Hingorani, Aroon D.; Marmot, Michael G.; Casas, Juan P.; Bobak, Martin.

In: Addiction, Vol. 109, No. 9, 09.2014, p. 1462-1471.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kumari, M, Holmes, MV, Dale, CE, Hubacek, JA, Palmer, TM, Pikhart, H, Peasey, A, Britton, A, Horvat, P, Kubinova, R, Malyutina, S, Pajak, A, Tamosiunas, A, Shankar, A, Singh-Manoux, A, Voevoda, M, Kivimaki, M, Hingorani, AD, Marmot, MG, Casas, JP & Bobak, M 2014, 'Alcohol consumption and cognitive performance: a Mendelian randomization study', Addiction, vol. 109, no. 9, pp. 1462-1471. https://doi.org/10.1111/add.12568

APA

Kumari, M., Holmes, M. V., Dale, C. E., Hubacek, J. A., Palmer, T. M., Pikhart, H., Peasey, A., Britton, A., Horvat, P., Kubinova, R., Malyutina, S., Pajak, A., Tamosiunas, A., Shankar, A., Singh-Manoux, A., Voevoda, M., Kivimaki, M., Hingorani, A. D., Marmot, M. G., ... Bobak, M. (2014). Alcohol consumption and cognitive performance: a Mendelian randomization study. Addiction, 109(9), 1462-1471. https://doi.org/10.1111/add.12568

Vancouver

Kumari M, Holmes MV, Dale CE, Hubacek JA, Palmer TM, Pikhart H et al. Alcohol consumption and cognitive performance: a Mendelian randomization study. Addiction. 2014 Sep;109(9):1462-1471. https://doi.org/10.1111/add.12568

Author

Kumari, Meena ; Holmes, Michael V. ; Dale, Caroline E. ; Hubacek, Jaroslav A. ; Palmer, Tom M. ; Pikhart, Hynek ; Peasey, Anne ; Britton, Annie ; Horvat, Pia ; Kubinova, Ruzena ; Malyutina, Sofia ; Pajak, Andrzej ; Tamosiunas, Abdonas ; Shankar, Aparna ; Singh-Manoux, Archana ; Voevoda, Mikhail ; Kivimaki, Mika ; Hingorani, Aroon D. ; Marmot, Michael G. ; Casas, Juan P. ; Bobak, Martin. / Alcohol consumption and cognitive performance : a Mendelian randomization study. In: Addiction. 2014 ; Vol. 109, No. 9. pp. 1462-1471.

Bibtex

@article{6e992320c6784966ad3b6431881942af,
title = "Alcohol consumption and cognitive performance: a Mendelian randomization study",
abstract = "AIMS: To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function.DESIGN: Mendelian randomization using a genetic variant related to alcohol intake (ADH1B rs1229984) was used to obtain unbiased estimates of the association between alcohol intake and cognitive performance.SETTING: Europe.PARTICIPANTS: More than 34 000 adults.MEASUREMENTS: Any versus no alcohol intake and units of intake in the previous week was measured by questionnaire. Cognitive function was assessed in terms of immediate and delayed word recall, verbal fluency and processing speed.FINDINGS: Having consumed any versus no alcohol was associated with higher scores by 0.17 standard deviations (SD) [95% confidence interval (CI) = 0.15, 0.20] for immediate recall, 0.17 SD (95% CI = 0.14, 0.19) for delayed recall, 0.17 SD (95% CI = 0.14, 0.19) for verbal fluency and 0.12 SD (95% CI = 0.09, 0.15) for processing speed. The minor allele of rs1229984 was associated with reduced odds of consuming any alcohol (odds ratio = 0.87; 95% CI = 0.80, 0.95; P = 0.001; R(2)  = 0.1%; F-statistic = 47). In Mendelian randomization analysis, the minor allele was not associated with any cognitive test score, and instrumental variable analysis suggested no causal association between alcohol consumption and cognition: -0.74 SD (95% CI = -1.88, 0.41) for immediate recall, -1.09 SD (95% CI = -2.38, 0.21) for delayed recall, -0.63 SD (95% CI = -1.78, 0.53) for verbal fluency and -0.16 SD (95% CI = -1.29, 0.97) for processing speed.CONCLUSIONS: The Mendelian randomization analysis did not provide strong evidence of a causal association between alcohol consumption and cognitive ability.",
keywords = "ADH1B, alcohol intake, cognition, memory, processing speed, verbal fluency",
author = "Meena Kumari and Holmes, {Michael V.} and Dale, {Caroline E.} and Hubacek, {Jaroslav A.} and Palmer, {Tom M.} and Hynek Pikhart and Anne Peasey and Annie Britton and Pia Horvat and Ruzena Kubinova and Sofia Malyutina and Andrzej Pajak and Abdonas Tamosiunas and Aparna Shankar and Archana Singh-Manoux and Mikhail Voevoda and Mika Kivimaki and Hingorani, {Aroon D.} and Marmot, {Michael G.} and Casas, {Juan P.} and Martin Bobak",
note = " {\textcopyright} 2014 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.",
year = "2014",
month = sep,
doi = "10.1111/add.12568",
language = "English",
volume = "109",
pages = "1462--1471",
journal = "Addiction",
issn = "0965-2140",
publisher = "Wiley",
number = "9",

}

RIS

TY - JOUR

T1 - Alcohol consumption and cognitive performance

T2 - a Mendelian randomization study

AU - Kumari, Meena

AU - Holmes, Michael V.

AU - Dale, Caroline E.

AU - Hubacek, Jaroslav A.

AU - Palmer, Tom M.

AU - Pikhart, Hynek

AU - Peasey, Anne

AU - Britton, Annie

AU - Horvat, Pia

AU - Kubinova, Ruzena

AU - Malyutina, Sofia

AU - Pajak, Andrzej

AU - Tamosiunas, Abdonas

AU - Shankar, Aparna

AU - Singh-Manoux, Archana

AU - Voevoda, Mikhail

AU - Kivimaki, Mika

AU - Hingorani, Aroon D.

AU - Marmot, Michael G.

AU - Casas, Juan P.

AU - Bobak, Martin

N1 - © 2014 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.

PY - 2014/9

Y1 - 2014/9

N2 - AIMS: To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function.DESIGN: Mendelian randomization using a genetic variant related to alcohol intake (ADH1B rs1229984) was used to obtain unbiased estimates of the association between alcohol intake and cognitive performance.SETTING: Europe.PARTICIPANTS: More than 34 000 adults.MEASUREMENTS: Any versus no alcohol intake and units of intake in the previous week was measured by questionnaire. Cognitive function was assessed in terms of immediate and delayed word recall, verbal fluency and processing speed.FINDINGS: Having consumed any versus no alcohol was associated with higher scores by 0.17 standard deviations (SD) [95% confidence interval (CI) = 0.15, 0.20] for immediate recall, 0.17 SD (95% CI = 0.14, 0.19) for delayed recall, 0.17 SD (95% CI = 0.14, 0.19) for verbal fluency and 0.12 SD (95% CI = 0.09, 0.15) for processing speed. The minor allele of rs1229984 was associated with reduced odds of consuming any alcohol (odds ratio = 0.87; 95% CI = 0.80, 0.95; P = 0.001; R(2)  = 0.1%; F-statistic = 47). In Mendelian randomization analysis, the minor allele was not associated with any cognitive test score, and instrumental variable analysis suggested no causal association between alcohol consumption and cognition: -0.74 SD (95% CI = -1.88, 0.41) for immediate recall, -1.09 SD (95% CI = -2.38, 0.21) for delayed recall, -0.63 SD (95% CI = -1.78, 0.53) for verbal fluency and -0.16 SD (95% CI = -1.29, 0.97) for processing speed.CONCLUSIONS: The Mendelian randomization analysis did not provide strong evidence of a causal association between alcohol consumption and cognitive ability.

AB - AIMS: To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function.DESIGN: Mendelian randomization using a genetic variant related to alcohol intake (ADH1B rs1229984) was used to obtain unbiased estimates of the association between alcohol intake and cognitive performance.SETTING: Europe.PARTICIPANTS: More than 34 000 adults.MEASUREMENTS: Any versus no alcohol intake and units of intake in the previous week was measured by questionnaire. Cognitive function was assessed in terms of immediate and delayed word recall, verbal fluency and processing speed.FINDINGS: Having consumed any versus no alcohol was associated with higher scores by 0.17 standard deviations (SD) [95% confidence interval (CI) = 0.15, 0.20] for immediate recall, 0.17 SD (95% CI = 0.14, 0.19) for delayed recall, 0.17 SD (95% CI = 0.14, 0.19) for verbal fluency and 0.12 SD (95% CI = 0.09, 0.15) for processing speed. The minor allele of rs1229984 was associated with reduced odds of consuming any alcohol (odds ratio = 0.87; 95% CI = 0.80, 0.95; P = 0.001; R(2)  = 0.1%; F-statistic = 47). In Mendelian randomization analysis, the minor allele was not associated with any cognitive test score, and instrumental variable analysis suggested no causal association between alcohol consumption and cognition: -0.74 SD (95% CI = -1.88, 0.41) for immediate recall, -1.09 SD (95% CI = -2.38, 0.21) for delayed recall, -0.63 SD (95% CI = -1.78, 0.53) for verbal fluency and -0.16 SD (95% CI = -1.29, 0.97) for processing speed.CONCLUSIONS: The Mendelian randomization analysis did not provide strong evidence of a causal association between alcohol consumption and cognitive ability.

KW - ADH1B

KW - alcohol intake

KW - cognition

KW - memory

KW - processing speed

KW - verbal fluency

U2 - 10.1111/add.12568

DO - 10.1111/add.12568

M3 - Journal article

C2 - 24716453

VL - 109

SP - 1462

EP - 1471

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 9

ER -