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An investigation of candidate regions for association with bipolar disorder

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Jo Knight
  • Nanette S. Rochberg
  • Scott F. Saccone
  • John I. Nurnberger
  • John P. Rice
  • NIMH Genetics Initiative Bipolar Disorder Consortium
<mark>Journal publication date</mark>5/10/2010
<mark>Journal</mark>American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Issue number7
Number of pages6
Pages (from-to)1292-1297
Publication StatusPublished
Early online date27/05/10
<mark>Original language</mark>English


We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.