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An investigation of candidate regions for association with bipolar disorder

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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An investigation of candidate regions for association with bipolar disorder. / Knight, Jo; Rochberg, Nanette S.; Saccone, Scott F. et al.
In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , Vol. 153B, No. 7, 05.10.2010, p. 1292-1297.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Knight, J, Rochberg, NS, Saccone, SF, Nurnberger, JI, Rice, JP & NIMH Genetics Initiative Bipolar Disorder Consortium 2010, 'An investigation of candidate regions for association with bipolar disorder', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , vol. 153B, no. 7, pp. 1292-1297. https://doi.org/10.1002/ajmg.b.31100

APA

Knight, J., Rochberg, N. S., Saccone, S. F., Nurnberger, J. I., Rice, J. P., & NIMH Genetics Initiative Bipolar Disorder Consortium (2010). An investigation of candidate regions for association with bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , 153B(7), 1292-1297. https://doi.org/10.1002/ajmg.b.31100

Vancouver

Knight J, Rochberg NS, Saccone SF, Nurnberger JI, Rice JP, NIMH Genetics Initiative Bipolar Disorder Consortium. An investigation of candidate regions for association with bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 2010 Oct 5;153B(7):1292-1297. Epub 2010 May 27. doi: 10.1002/ajmg.b.31100

Author

Knight, Jo ; Rochberg, Nanette S. ; Saccone, Scott F. et al. / An investigation of candidate regions for association with bipolar disorder. In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 2010 ; Vol. 153B, No. 7. pp. 1292-1297.

Bibtex

@article{e4fef8e1a51043ed91cb675189404aed,
title = "An investigation of candidate regions for association with bipolar disorder",
abstract = "We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.",
keywords = "Adenosine Triphosphatases, Bipolar Disorder, Case-Control Studies, Chromosomes, Human, Pair 6, Genetic Association Studies, Genetic Markers, Genotype, Humans, Polymorphism, Single Nucleotide",
author = "Jo Knight and Rochberg, {Nanette S.} and Saccone, {Scott F.} and Nurnberger, {John I.} and Rice, {John P.} and {NIMH Genetics Initiative Bipolar Disorder Consortium}",
year = "2010",
month = oct,
day = "5",
doi = "10.1002/ajmg.b.31100",
language = "English",
volume = "153B",
pages = "1292--1297",
journal = "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics ",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - An investigation of candidate regions for association with bipolar disorder

AU - Knight, Jo

AU - Rochberg, Nanette S.

AU - Saccone, Scott F.

AU - Nurnberger, John I.

AU - Rice, John P.

AU - NIMH Genetics Initiative Bipolar Disorder Consortium

PY - 2010/10/5

Y1 - 2010/10/5

N2 - We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.

AB - We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.

KW - Adenosine Triphosphatases

KW - Bipolar Disorder

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 6

KW - Genetic Association Studies

KW - Genetic Markers

KW - Genotype

KW - Humans

KW - Polymorphism, Single Nucleotide

U2 - 10.1002/ajmg.b.31100

DO - 10.1002/ajmg.b.31100

M3 - Journal article

C2 - 20872768

VL - 153B

SP - 1292

EP - 1297

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 7

ER -