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Anti-arrhythmic effects of atrial specific IKur block: A simulation study

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

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Anti-arrhythmic effects of atrial specific IKur block: A simulation study. / Law, P.; Kharche, S.; Higham, J. et al.
2010 Computing in Cardiology. IEEE, 2011.

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

Harvard

Law, P, Kharche, S, Higham, J & Zhang, H 2011, Anti-arrhythmic effects of atrial specific IKur block: A simulation study. in 2010 Computing in Cardiology. IEEE. <https://ieeexplore.ieee.org/document/5738001>

APA

Law, P., Kharche, S., Higham, J., & Zhang, H. (2011). Anti-arrhythmic effects of atrial specific IKur block: A simulation study. In 2010 Computing in Cardiology IEEE. https://ieeexplore.ieee.org/document/5738001

Vancouver

Law P, Kharche S, Higham J, Zhang H. Anti-arrhythmic effects of atrial specific IKur block: A simulation study. In 2010 Computing in Cardiology. IEEE. 2011 Epub 2010 Sept 26.

Author

Law, P. ; Kharche, S. ; Higham, J. et al. / Anti-arrhythmic effects of atrial specific IKur block : A simulation study. 2010 Computing in Cardiology. IEEE, 2011.

Bibtex

@inproceedings{59c2a92a3f86420ca28f85b30e29982c,
title = "Anti-arrhythmic effects of atrial specific IKur block: A simulation study",
abstract = "The ultra rapid potassium current (IKur) is an attractive pharmacological target in atrial fibrillation (AF) management due to its atrial specific nature. An experimentally based 78% IKur reduction was incorporated into a human atrial action potential (AP) model under sinus rhythm (SR) and atrial fibrillation (AF) conditions. Its effects on cell and tissue level electrical activity were simulated. IKur block reduced AP duration (APD) and effective refractory period (ERP) under SR conditions, but prolonged APD and ERP under AF conditions. IKur block modulated tissue's ability to sustain high pacing rate conduction under SR and AF conditions. Vulnerability window (VW) was augmented under SR, and reduced under AF conditions. IKur block did not effect on re-entrant waves in 2D and 3D simulations. Simulations show pro-arrhythmic effects in SR, but anti-arrhythmic effects in AF case due to IKur block.",
author = "P. Law and S. Kharche and J. Higham and H. Zhang",
year = "2011",
month = mar,
day = "22",
language = "English",
isbn = "9781424473182",
booktitle = "2010 Computing in Cardiology",
publisher = "IEEE",

}

RIS

TY - GEN

T1 - Anti-arrhythmic effects of atrial specific IKur block

T2 - A simulation study

AU - Law, P.

AU - Kharche, S.

AU - Higham, J.

AU - Zhang, H.

PY - 2011/3/22

Y1 - 2011/3/22

N2 - The ultra rapid potassium current (IKur) is an attractive pharmacological target in atrial fibrillation (AF) management due to its atrial specific nature. An experimentally based 78% IKur reduction was incorporated into a human atrial action potential (AP) model under sinus rhythm (SR) and atrial fibrillation (AF) conditions. Its effects on cell and tissue level electrical activity were simulated. IKur block reduced AP duration (APD) and effective refractory period (ERP) under SR conditions, but prolonged APD and ERP under AF conditions. IKur block modulated tissue's ability to sustain high pacing rate conduction under SR and AF conditions. Vulnerability window (VW) was augmented under SR, and reduced under AF conditions. IKur block did not effect on re-entrant waves in 2D and 3D simulations. Simulations show pro-arrhythmic effects in SR, but anti-arrhythmic effects in AF case due to IKur block.

AB - The ultra rapid potassium current (IKur) is an attractive pharmacological target in atrial fibrillation (AF) management due to its atrial specific nature. An experimentally based 78% IKur reduction was incorporated into a human atrial action potential (AP) model under sinus rhythm (SR) and atrial fibrillation (AF) conditions. Its effects on cell and tissue level electrical activity were simulated. IKur block reduced AP duration (APD) and effective refractory period (ERP) under SR conditions, but prolonged APD and ERP under AF conditions. IKur block modulated tissue's ability to sustain high pacing rate conduction under SR and AF conditions. Vulnerability window (VW) was augmented under SR, and reduced under AF conditions. IKur block did not effect on re-entrant waves in 2D and 3D simulations. Simulations show pro-arrhythmic effects in SR, but anti-arrhythmic effects in AF case due to IKur block.

M3 - Conference contribution/Paper

SN - 9781424473182

BT - 2010 Computing in Cardiology

PB - IEEE

ER -