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Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Neil Pendleton
  • Anthony Payton
  • Eelke van den Boogerd
  • Fiona Holland
  • Peter J. Diggle
  • Patrick M. A. Rabbitt
  • Michael A. Horan
  • Jane Worthington
  • William E. R. Ollier
<mark>Journal publication date</mark>10/05/2002
<mark>Journal</mark>Neuroscience Letters
Issue number1
Number of pages3
Pages (from-to)74-76
Publication StatusPublished
<mark>Original language</mark>English


There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.