Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.

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Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. / Pendleton, Neil; Payton, Anthony; van den Boogerd, Eelke et al.
In: Neuroscience Letters, Vol. 324, No. 1, 10.05.2002, p. 74-76.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Pendleton, N, Payton, A, van den Boogerd, E, Holland, F, Diggle, PJ, Rabbitt, PMA, Horan, MA, Worthington, J & Ollier, WER 2002, 'Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.', Neuroscience Letters, vol. 324, no. 1, pp. 74-76. https://doi.org/10.1016/S0304-3940(02)00135-0

APA

Pendleton, N., Payton, A., van den Boogerd, E., Holland, F., Diggle, P. J., Rabbitt, P. M. A., Horan, M. A., Worthington, J., & Ollier, W. E. R. (2002). Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neuroscience Letters, 324(1), 74-76. https://doi.org/10.1016/S0304-3940(02)00135-0

Vancouver

Pendleton N, Payton A, van den Boogerd E, Holland F, Diggle PJ, Rabbitt PMA et al. Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neuroscience Letters. 2002 May 10;324(1):74-76. doi: 10.1016/S0304-3940(02)00135-0

Author

Pendleton, Neil ; Payton, Anthony ; van den Boogerd, Eelke et al. / Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. In: Neuroscience Letters. 2002 ; Vol. 324, No. 1. pp. 74-76.

Bibtex

@article{4ad69b75015b441e96d57b41e392d1be,

title = "Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.",

abstract = "There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.",

keywords = "Apolipoprotein E, Intelligence, Genetics, Aged",

author = "Neil Pendleton and Anthony Payton and {van den Boogerd}, Eelke and Fiona Holland and Diggle, {Peter J.} and Rabbitt, {Patrick M. A.} and Horan, {Michael A.} and Jane Worthington and Ollier, {William E. R.}",

year = "2002",

month = may,

day = "10",

doi = "10.1016/S0304-3940(02)00135-0",

language = "English",

volume = "324",

pages = "74--76",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults.

AU - Pendleton, Neil

AU - Payton, Anthony

AU - van den Boogerd, Eelke

AU - Holland, Fiona

AU - Diggle, Peter J.

AU - Rabbitt, Patrick M. A.

AU - Horan, Michael A.

AU - Worthington, Jane

AU - Ollier, William E. R.

PY - 2002/5/10

Y1 - 2002/5/10

N2 - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

AB - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

KW - Apolipoprotein E

KW - Intelligence

KW - Genetics

KW - Aged

U2 - 10.1016/S0304-3940(02)00135-0

DO - 10.1016/S0304-3940(02)00135-0

M3 - Journal article

VL - 324

SP - 74

EP - 76

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -

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