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Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks

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Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. / Hoffmann, Sebastian; Aiassa, Elisa; Angrish, Michelle et al.
In: Altex, Vol. 39, No. 3, 20.07.2022, p. 499–518.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hoffmann, S, Aiassa, E, Angrish, M, Beausoleil, C, Bois, FY, Ciccolallo, L, Craig, PS, De Vries, RBM, Dorne, JLCM, Druwe, IL, Edwards, SW, Eskes, C, Georgiadis, M, Hartung, T, Kienzler, A, Kristjansson, EA, Lam, J, Martino, L, Meek, B, Morgan, RL, Munoz-Guajardo, I, Noyes, PD, Parmelli, E, Piersma, A, Rooney, A, Sena, E, Sullivan, K, Tarazona, J, Terron, A, Thayer, K, Turner, J, Verbeek, J, Verloo, D, Vinken, M, Watford, S, Whaley, P, Wikoff, D, Willett, K & Tsaioun, K 2022, 'Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks', Altex, vol. 39, no. 3, pp. 499–518. https://doi.org/10.14573/altex.2202141

APA

Hoffmann, S., Aiassa, E., Angrish, M., Beausoleil, C., Bois, F. Y., Ciccolallo, L., Craig, P. S., De Vries, R. B. M., Dorne, J. L. C. M., Druwe, I. L., Edwards, S. W., Eskes, C., Georgiadis, M., Hartung, T., Kienzler, A., Kristjansson, E. A., Lam, J., Martino, L., Meek, B., ... Tsaioun, K. (2022). Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. Altex, 39(3), 499–518. https://doi.org/10.14573/altex.2202141

Vancouver

Hoffmann S, Aiassa E, Angrish M, Beausoleil C, Bois FY, Ciccolallo L et al. Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. Altex. 2022 Jul 20;39(3):499–518. Epub 2022 Mar 1. doi: 10.14573/altex.2202141

Author

Hoffmann, Sebastian ; Aiassa, Elisa ; Angrish, Michelle et al. / Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. In: Altex. 2022 ; Vol. 39, No. 3. pp. 499–518.

Bibtex

@article{824d9755fca744de9b2723b19e0a37da,
title = "Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks",
abstract = "The workshop titled {"}Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks{"} was co-organized by the Evidence-based Toxicology Collaboration and the European Food Safety Authority (EFSA), and hosted by EFSA at its headquarters in Parma, Italy on October 2 and 3, 2019. The goal was to explore integration of systematic review methods with mechanistic evidence evaluation. Participants were invited to work on concrete products to advance the exploration of how evidence-based approaches can support the development and application of adverse outcome pathways (AOP) in chemical risk assessment. The workshop discussions were centered around three related themes: 1) assessing certainty in AOPs, 2) literature-based AOP development and 3) integrating certainty in AOPs and non-animal evidence into decision frameworks. Several challenges, mostly related to methodology, were identified, and largely determined the workshop recommendations. The workshop recommendations included the comparison and potential alignment of processes used to develop AOP and systematic review methodology, including the translation of vocabulary of evidence-based methods to AOP and vice versa, the development and improvement of evidence mapping and text mining methods and tools, as well as a call for a fundamental change in chemical risk and uncertainty assessment methodology if to be conducted based on AOPs and new approach methodologies (NAM). The usefulness of evidence-based approaches for mechanism-based chemical risk assessments was stressed, particularly the potential contribution of the rigor and transparency inherent to such approaches in building stakeholders' trust for implementation of NAM evidence and AOP into chemical risk assessment.",
keywords = "new approach methodologies, certainty assessment, systematic evidence synthesis, adverse outcome pathway, evidence-based toxicology",
author = "Sebastian Hoffmann and Elisa Aiassa and Michelle Angrish and Claire Beausoleil and Bois, {Frederic Y} and Laura Ciccolallo and Craig, {Peter S} and {De Vries}, {Rob B M} and Dorne, {Jean Lou C M} and Druwe, {Ingrid L} and Edwards, {Stephen W} and Chantra Eskes and Marios Georgiadis and Thomas Hartung and Aude Kienzler and Kristjansson, {Elisabeth A} and Juleen Lam and Laura Martino and Bette Meek and Morgan, {Rebecca L} and Irene Munoz-Guajardo and Noyes, {Pamela D} and Elena Parmelli and Aldert Piersma and Andrew Rooney and Emily Sena and Kristie Sullivan and Jos{\'e} Tarazona and Andrea Terron and Kris Thayer and Jan Turner and Jos Verbeek and Didier Verloo and Mathieu Vinken and Sean Watford and Paul Whaley and Daniele Wikoff and Kate Willett and Katya Tsaioun",
year = "2022",
month = jul,
day = "20",
doi = "10.14573/altex.2202141",
language = "English",
volume = "39",
pages = "499–518",
journal = "Altex",
issn = "1868-596X",
publisher = "ALTEX Edition",
number = "3",

}

RIS

TY - JOUR

T1 - Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks

AU - Hoffmann, Sebastian

AU - Aiassa, Elisa

AU - Angrish, Michelle

AU - Beausoleil, Claire

AU - Bois, Frederic Y

AU - Ciccolallo, Laura

AU - Craig, Peter S

AU - De Vries, Rob B M

AU - Dorne, Jean Lou C M

AU - Druwe, Ingrid L

AU - Edwards, Stephen W

AU - Eskes, Chantra

AU - Georgiadis, Marios

AU - Hartung, Thomas

AU - Kienzler, Aude

AU - Kristjansson, Elisabeth A

AU - Lam, Juleen

AU - Martino, Laura

AU - Meek, Bette

AU - Morgan, Rebecca L

AU - Munoz-Guajardo, Irene

AU - Noyes, Pamela D

AU - Parmelli, Elena

AU - Piersma, Aldert

AU - Rooney, Andrew

AU - Sena, Emily

AU - Sullivan, Kristie

AU - Tarazona, José

AU - Terron, Andrea

AU - Thayer, Kris

AU - Turner, Jan

AU - Verbeek, Jos

AU - Verloo, Didier

AU - Vinken, Mathieu

AU - Watford, Sean

AU - Whaley, Paul

AU - Wikoff, Daniele

AU - Willett, Kate

AU - Tsaioun, Katya

PY - 2022/7/20

Y1 - 2022/7/20

N2 - The workshop titled "Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks" was co-organized by the Evidence-based Toxicology Collaboration and the European Food Safety Authority (EFSA), and hosted by EFSA at its headquarters in Parma, Italy on October 2 and 3, 2019. The goal was to explore integration of systematic review methods with mechanistic evidence evaluation. Participants were invited to work on concrete products to advance the exploration of how evidence-based approaches can support the development and application of adverse outcome pathways (AOP) in chemical risk assessment. The workshop discussions were centered around three related themes: 1) assessing certainty in AOPs, 2) literature-based AOP development and 3) integrating certainty in AOPs and non-animal evidence into decision frameworks. Several challenges, mostly related to methodology, were identified, and largely determined the workshop recommendations. The workshop recommendations included the comparison and potential alignment of processes used to develop AOP and systematic review methodology, including the translation of vocabulary of evidence-based methods to AOP and vice versa, the development and improvement of evidence mapping and text mining methods and tools, as well as a call for a fundamental change in chemical risk and uncertainty assessment methodology if to be conducted based on AOPs and new approach methodologies (NAM). The usefulness of evidence-based approaches for mechanism-based chemical risk assessments was stressed, particularly the potential contribution of the rigor and transparency inherent to such approaches in building stakeholders' trust for implementation of NAM evidence and AOP into chemical risk assessment.

AB - The workshop titled "Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks" was co-organized by the Evidence-based Toxicology Collaboration and the European Food Safety Authority (EFSA), and hosted by EFSA at its headquarters in Parma, Italy on October 2 and 3, 2019. The goal was to explore integration of systematic review methods with mechanistic evidence evaluation. Participants were invited to work on concrete products to advance the exploration of how evidence-based approaches can support the development and application of adverse outcome pathways (AOP) in chemical risk assessment. The workshop discussions were centered around three related themes: 1) assessing certainty in AOPs, 2) literature-based AOP development and 3) integrating certainty in AOPs and non-animal evidence into decision frameworks. Several challenges, mostly related to methodology, were identified, and largely determined the workshop recommendations. The workshop recommendations included the comparison and potential alignment of processes used to develop AOP and systematic review methodology, including the translation of vocabulary of evidence-based methods to AOP and vice versa, the development and improvement of evidence mapping and text mining methods and tools, as well as a call for a fundamental change in chemical risk and uncertainty assessment methodology if to be conducted based on AOPs and new approach methodologies (NAM). The usefulness of evidence-based approaches for mechanism-based chemical risk assessments was stressed, particularly the potential contribution of the rigor and transparency inherent to such approaches in building stakeholders' trust for implementation of NAM evidence and AOP into chemical risk assessment.

KW - new approach methodologies

KW - certainty assessment

KW - systematic evidence synthesis

KW - adverse outcome pathway

KW - evidence-based toxicology

U2 - 10.14573/altex.2202141

DO - 10.14573/altex.2202141

M3 - Journal article

C2 - 35258090

VL - 39

SP - 499

EP - 518

JO - Altex

JF - Altex

SN - 1868-596X

IS - 3

ER -