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Associations of mortality with own height using son's height as an instrumental variable

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Associations of mortality with own height using son's height as an instrumental variable. / Carslake, David; Fraser, Abigail; Davey Smith, George; May, Margaret; Palmer, Tom; Sterne, Jonathan; Silventoinen, Karri; Tynelius, Per; Lawlor, Debbie A.; Rasmussen, Finn.

In: Economics and Human Biology, Vol. 11, No. 3, 07.2013, p. 351-359.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Carslake, D, Fraser, A, Davey Smith, G, May, M, Palmer, T, Sterne, J, Silventoinen, K, Tynelius, P, Lawlor, DA & Rasmussen, F 2013, 'Associations of mortality with own height using son's height as an instrumental variable', Economics and Human Biology, vol. 11, no. 3, pp. 351-359. https://doi.org/10.1016/j.ehb.2012.04.003

APA

Carslake, D., Fraser, A., Davey Smith, G., May, M., Palmer, T., Sterne, J., Silventoinen, K., Tynelius, P., Lawlor, D. A., & Rasmussen, F. (2013). Associations of mortality with own height using son's height as an instrumental variable. Economics and Human Biology, 11(3), 351-359. https://doi.org/10.1016/j.ehb.2012.04.003

Vancouver

Carslake D, Fraser A, Davey Smith G, May M, Palmer T, Sterne J et al. Associations of mortality with own height using son's height as an instrumental variable. Economics and Human Biology. 2013 Jul;11(3):351-359. https://doi.org/10.1016/j.ehb.2012.04.003

Author

Carslake, David ; Fraser, Abigail ; Davey Smith, George ; May, Margaret ; Palmer, Tom ; Sterne, Jonathan ; Silventoinen, Karri ; Tynelius, Per ; Lawlor, Debbie A. ; Rasmussen, Finn. / Associations of mortality with own height using son's height as an instrumental variable. In: Economics and Human Biology. 2013 ; Vol. 11, No. 3. pp. 351-359.

Bibtex

@article{eee26e3de0ee4783ab8409f6e41a1b89,
title = "Associations of mortality with own height using son's height as an instrumental variable",
abstract = "Height is associated with mortality from many diseases, but it remains unclear whether the association is causal or due to confounding by social factors, genetic pleiotropy,(1) or existing ill-health. The authors investigated whether the association of height with mortality is causal by using a son's height as an instrumental variable (IV) for parents' height among the parents of a cohort of 1,036,963 Swedish men born between 1951 and 1980 who had their height measured at military conscription, aged around 18, between 1969 and 2001. In a two-sample IV analysis adjusting for son's age at examination and secular trends in height, as well as parental age, and socioeconomic position, the hazard ratio (HR) for all-cause paternal mortality per standard deviation (SD, 6.49cm) of height was 0.96 (95% confidence interval (CI): 0.95, 0.96). The results of IV analyses of mortality from all causes, cardiovascular disease (CVD), respiratory disease, cancer, external causes and suicide were comparable to those obtained using son's height as a simple proxy for own height and to conventional analyses of own height in the present data and elsewhere, suggesting that such conventional analyses are not substantially confounded by existing ill-health.",
keywords = "Adolescent, Adult, Body Height, Cause of Death, Confidence Intervals, Confounding Factors (Epidemiology), Female, Humans, Longitudinal Studies, Male, Nuclear Family, Proportional Hazards Models, Sweden, Young Adult",
author = "David Carslake and Abigail Fraser and {Davey Smith}, George and Margaret May and Tom Palmer and Jonathan Sterne and Karri Silventoinen and Per Tynelius and Lawlor, {Debbie A.} and Finn Rasmussen",
note = " Copyright {\textcopyright} 2012 Elsevier B.V. All rights reserved.",
year = "2013",
month = jul,
doi = "10.1016/j.ehb.2012.04.003",
language = "English",
volume = "11",
pages = "351--359",
journal = "Economics and Human Biology",
issn = "1570-677X",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Associations of mortality with own height using son's height as an instrumental variable

AU - Carslake, David

AU - Fraser, Abigail

AU - Davey Smith, George

AU - May, Margaret

AU - Palmer, Tom

AU - Sterne, Jonathan

AU - Silventoinen, Karri

AU - Tynelius, Per

AU - Lawlor, Debbie A.

AU - Rasmussen, Finn

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2013/7

Y1 - 2013/7

N2 - Height is associated with mortality from many diseases, but it remains unclear whether the association is causal or due to confounding by social factors, genetic pleiotropy,(1) or existing ill-health. The authors investigated whether the association of height with mortality is causal by using a son's height as an instrumental variable (IV) for parents' height among the parents of a cohort of 1,036,963 Swedish men born between 1951 and 1980 who had their height measured at military conscription, aged around 18, between 1969 and 2001. In a two-sample IV analysis adjusting for son's age at examination and secular trends in height, as well as parental age, and socioeconomic position, the hazard ratio (HR) for all-cause paternal mortality per standard deviation (SD, 6.49cm) of height was 0.96 (95% confidence interval (CI): 0.95, 0.96). The results of IV analyses of mortality from all causes, cardiovascular disease (CVD), respiratory disease, cancer, external causes and suicide were comparable to those obtained using son's height as a simple proxy for own height and to conventional analyses of own height in the present data and elsewhere, suggesting that such conventional analyses are not substantially confounded by existing ill-health.

AB - Height is associated with mortality from many diseases, but it remains unclear whether the association is causal or due to confounding by social factors, genetic pleiotropy,(1) or existing ill-health. The authors investigated whether the association of height with mortality is causal by using a son's height as an instrumental variable (IV) for parents' height among the parents of a cohort of 1,036,963 Swedish men born between 1951 and 1980 who had their height measured at military conscription, aged around 18, between 1969 and 2001. In a two-sample IV analysis adjusting for son's age at examination and secular trends in height, as well as parental age, and socioeconomic position, the hazard ratio (HR) for all-cause paternal mortality per standard deviation (SD, 6.49cm) of height was 0.96 (95% confidence interval (CI): 0.95, 0.96). The results of IV analyses of mortality from all causes, cardiovascular disease (CVD), respiratory disease, cancer, external causes and suicide were comparable to those obtained using son's height as a simple proxy for own height and to conventional analyses of own height in the present data and elsewhere, suggesting that such conventional analyses are not substantially confounded by existing ill-health.

KW - Adolescent

KW - Adult

KW - Body Height

KW - Cause of Death

KW - Confidence Intervals

KW - Confounding Factors (Epidemiology)

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Nuclear Family

KW - Proportional Hazards Models

KW - Sweden

KW - Young Adult

U2 - 10.1016/j.ehb.2012.04.003

DO - 10.1016/j.ehb.2012.04.003

M3 - Journal article

C2 - 22560304

VL - 11

SP - 351

EP - 359

JO - Economics and Human Biology

JF - Economics and Human Biology

SN - 1570-677X

IS - 3

ER -