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Asymmetric aziridine synthesis via aza-Darzens reaction of bromoacylcamphorsultam

Research output: Contribution to journalJournal articlepeer-review

Published
  • Alex A. Cantrill
  • Lee D. Hall
  • Ashley N. Jarvis
  • Helen M.I. Osborn
  • Jenny Raphy
  • J. B. Sweeney
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<mark>Journal publication date</mark>1/01/1996
<mark>Journal</mark>Chemical Communications
Issue number23
Volume1996
Number of pages2
Pages (from-to)2631-2632
Publication StatusPublished
<mark>Original language</mark>English

Abstract

The aza-Darzens reaction of the chiral enolate derived from bromoacetylcamphorsultam 1 with N-(diphenylphosphinyl)aryl- and tert-butyl-methanimines proceeds in good yield to give cis-N-(diphenylphosphinyl)aziridinylcarbonyl sultams with high de. Monochiral cis-aziridinecarboxylates may be obtained in acceptable yield by hydrolysis of these sultams.