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Autophagy promotes visceral aging in wild-type C. elegans

Research output: Contribution to Journal/MagazineJournal articlepeer-review

<mark>Journal publication date</mark>3/04/2019
Issue number4
Number of pages2
Pages (from-to)737-732
Publication StatusPublished
Early online date30/01/19
<mark>Original language</mark>English


A plethora of studies over several decades has demonstrated the importance of autophagy in aging and age-related neurodegenerative disease. The role of autophagy in damage clearance and cell survival is well established, and supports a prevailing view that increasing autophagic activity can be broadly beneficial, and could form the basis of anti-aging interventions. However, macroautophagy/autophagy also promotes some elements of senescence. For example, in C. elegans hermaphrodites it facilitates conversion of intestinal biomass into yolk, leading to sex-specific gut atrophy and senescent steatosis.