Home > Research > Publications & Outputs > Autophagy promotes visceral aging in wild-type ...

Electronic data

Links

Text available via DOI:

View graph of relations

Autophagy promotes visceral aging in wild-type C. elegans

Research output: Contribution to journalJournal articlepeer-review

Published
<mark>Journal publication date</mark>3/04/2019
<mark>Journal</mark>Autophagy
Issue number4
Volume15
Number of pages2
Pages (from-to)737-732
Publication StatusPublished
Early online date30/01/19
<mark>Original language</mark>English

Abstract

A plethora of studies over several decades has demonstrated the importance of autophagy in aging and age-related neurodegenerative disease. The role of autophagy in damage clearance and cell survival is well established, and supports a prevailing view that increasing autophagic activity can be broadly beneficial, and could form the basis of anti-aging interventions. However, macroautophagy/autophagy also promotes some elements of senescence. For example, in C. elegans hermaphrodites it facilitates conversion of intestinal biomass into yolk, leading to sex-specific gut atrophy and senescent steatosis.