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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Autophagy promotes visceral aging in wild-type C. elegans
AU - Benedetto, Alexandre
AU - Gems, David
PY - 2019/4/3
Y1 - 2019/4/3
N2 - A plethora of studies over several decades has demonstrated the importance of autophagy in aging and age-related neurodegenerative disease. The role of autophagy in damage clearance and cell survival is well established, and supports a prevailing view that increasing autophagic activity can be broadly beneficial, and could form the basis of anti-aging interventions. However, macroautophagy/autophagy also promotes some elements of senescence. For example, in C. elegans hermaphrodites it facilitates conversion of intestinal biomass into yolk, leading to sex-specific gut atrophy and senescent steatosis.
AB - A plethora of studies over several decades has demonstrated the importance of autophagy in aging and age-related neurodegenerative disease. The role of autophagy in damage clearance and cell survival is well established, and supports a prevailing view that increasing autophagic activity can be broadly beneficial, and could form the basis of anti-aging interventions. However, macroautophagy/autophagy also promotes some elements of senescence. For example, in C. elegans hermaphrodites it facilitates conversion of intestinal biomass into yolk, leading to sex-specific gut atrophy and senescent steatosis.
KW - Autophagy
KW - C. elegans
KW - ageing
KW - Oxidative stress
KW - Gut infection
KW - E. faecalis
KW - Thermal stress
U2 - 10.1080/15548627.2019.1569919
DO - 10.1080/15548627.2019.1569919
M3 - Journal article
VL - 15
SP - 737
EP - 732
JO - Autophagy
JF - Autophagy
SN - 1554-8627
IS - 4
ER -