Home > Research > Publications & Outputs > Baseline factors associated with early and late...

Links

Text available via DOI:

View graph of relations

Baseline factors associated with early and late death in intracerebral haemorrhage survivors

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published
  • G. Banerjee
  • G. Ambler
  • I. C. Hostettler
  • C. Shakeshaft
  • S. Lunawat
  • H. Cohen
  • T. Yousry
  • R. Al-Shahi Salman
  • G. Y.H. Lip
  • H. Houlden
  • K. W. Muir
  • H. R. Jäger
  • D. J. Werring
  • Louise Shaw
  • Kirsty Harkness
  • Jane Sword
  • Azlisham Mohd Nor
  • Pankaj Sharma
  • Deborah Kelly
  • Frances Harrington
  • Marc Randall
  • Matthew Smith
  • Karim Mahawish
  • Abduelbaset Elmarim
  • Bernard Esisi
  • Claire Cullen
  • Arumug Nallasivam
  • Christopher Price
  • Adrian Barry
  • Christine Roffe
  • John Coyle
  • Ahamad Hassan
  • Caroline Lovelock
  • Jonathan Birns
  • David Cohen
  • L. Sekaran
  • Adrian Parry-Jones
  • Anthea Parry
  • David Hargroves
  • Harald Proschel
  • Prabel Datta
  • Khaled Darawil
  • Aravindakshan Manoj
  • Mathew Burn
  • Chris Patterson
  • Elio Giallombardo
  • Nigel Smyth
  • Syed Mansoor
  • Ijaz Anwar
  • Rachel Marsh
  • Sissi Ispoglou
  • Dinesh Chadha
  • Mathuri Prabhakaran
  • Sanjeevikumar Meenakishundaram
  • Janice O'Connell
  • Jon Scott
  • Vinodh Krishnamurthy
  • Prasanna Aghoram
  • Michael McCormick
  • Paul O’Mahony
  • Martin Cooper
  • Lillian Choy
  • Peter Wilkinson
  • Simon Leach
  • Sarah Caine
  • Ilse Burger
  • Gunaratam Gunathilagan
  • Paul Guyler
  • Michelle Davis
  • Dulka Manawadu
  • Kath Pasco
  • Maam Mamun
  • Robert Luder
  • Mahmud Sajid
  • Ijaz Anwar
  • James Okwera
  • Julie Staals
  • Elizabeth Warburton
  • Kari Saastamoinen
  • Timothy England
  • Janet Putterill
  • Enrico Flossman
  • Michael Power
  • Krishna Dani
  • David Mangion
  • Appu Suman
  • John Corrigan
  • Enas Lawrence
  • Djamil Vahidassr
Close
<mark>Journal publication date</mark>1/07/2020
<mark>Journal</mark>European Journal of Neurology
Issue number7
Volume27
Number of pages7
Pages (from-to)1257-1263
Publication StatusPublished
Early online date29/03/20
<mark>Original language</mark>English

Abstract

Background and purpose: The aim of this study was to determine whether early and late death are associated with different baseline factors in intracerebral haemorrhage (ICH) survivors. Methods: This was a secondary analysis of the multicentre prospective observational CROMIS-2 ICH study. Death was defined as ‘early’ if occurring within 6 months of study entry and ‘late’ if occurring after this time point. Results: In our cohort (n = 1094), there were 306 deaths (per 100 patient-years: absolute event rate, 11.7; 95% confidence intervals, 10.5–13.1); 156 were ‘early’ and 150 ‘late’. In multivariable analyses, early death was independently associated with age [per year increase; hazard ratio (HR), 1.05, P = 0.003], history of hypertension (HR, 1.89, P = 0.038), pre-event modified Rankin scale score (per point increase; HR, 1.41, P < 0.0001), admission National Institutes of Health Stroke Scale score (per point increase; HR, 1.11, P < 0.0001) and haemorrhage volume >60 mL (HR, 4.08, P < 0.0001). Late death showed independent associations with age (per year increase; HR, 1.04, P = 0.003), pre-event modified Rankin scale score (per point increase; HR, 1.42, P = 0.001), prior anticoagulant use (HR, 2.13, P = 0.028) and the presence of intraventricular extension (HR, 1.73, P = 0.033) in multivariable analyses. In further analyses where time was treated as continuous (rather than dichotomized), the HR of previous cerebral ischaemic events increased with time, whereas HRs for Glasgow Coma Scale score, National Institutes of Health Stroke Scale score and ICH volume decreased over time. Conclusions: We provide new evidence that not all baseline factors associated with early mortality after ICH are associated with mortality after 6 months and that the effects of baseline variables change over time. Our findings could help design better prognostic scores for later death after ICH.