Home > Research > Publications & Outputs > Baseline factors associated with early and late...

Research

Associated organisational unit

Links

Text available via DOI:

Keywords

View graph of relations

Baseline factors associated with early and late death in intracerebral haemorrhage survivors

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Baseline factors associated with early and late death in intracerebral haemorrhage survivors. / Banerjee, G.; Ambler, G.; Hostettler, I. C. et al.
In: European Journal of Neurology, Vol. 27, No. 7, 01.07.2020, p. 1257-1263.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Banerjee, G, Ambler, G, Hostettler, IC, Shakeshaft, C, Lunawat, S, Cohen, H, Yousry, T, Al-Shahi Salman, R, Lip, GYH, Houlden, H, Muir, KW, Jäger, HR, Werring, DJ, Shaw, L, Harkness, K, Sword, J, Mohd Nor, A, Sharma, P, Kelly, D, Harrington, F, Randall, M, Smith, M, Mahawish, K, Elmarim, A, Esisi, B, Cullen, C, Nallasivam, A, Price, C, Barry, A, Roffe, C, Coyle, J, Hassan, A, Lovelock, C, Birns, J, Cohen, D, Sekaran, L, Parry-Jones, A, Parry, A, Hargroves, D, Proschel, H, Datta, P, Darawil, K, Manoj, A, Burn, M, Patterson, C, Giallombardo, E, Smyth, N, Mansoor, S, Anwar, I, Marsh, R, Ispoglou, S, Chadha, D, Prabhakaran, M, Meenakishundaram, S, O'Connell, J, Scott, J, Krishnamurthy, V, Aghoram, P, McCormick, M, O’Mahony, P, Cooper, M, Choy, L, Wilkinson, P, Leach, S, Caine, S, Burger, I, Gunathilagan, G, Guyler, P, Emsley, H, Davis, M, Manawadu, D, Pasco, K, Mamun, M, Luder, R, Sajid, M, Anwar, I, Okwera, J, Staals, J, Warburton, E, Saastamoinen, K, England, T, Putterill, J, Flossman, E, Power, M, Dani, K, Mangion, D, Suman, A, Corrigan, J, Lawrence, E & Vahidassr, D 2020, 'Baseline factors associated with early and late death in intracerebral haemorrhage survivors', European Journal of Neurology, vol. 27, no. 7, pp. 1257-1263. https://doi.org/10.1111/ene.14238

APA

Banerjee, G., Ambler, G., Hostettler, I. C., Shakeshaft, C., Lunawat, S., Cohen, H., Yousry, T., Al-Shahi Salman, R., Lip, G. Y. H., Houlden, H., Muir, K. W., Jäger, H. R., Werring, D. J., Shaw, L., Harkness, K., Sword, J., Mohd Nor, A., Sharma, P., Kelly, D., ... Vahidassr, D. (2020). Baseline factors associated with early and late death in intracerebral haemorrhage survivors. European Journal of Neurology, 27(7), 1257-1263. https://doi.org/10.1111/ene.14238

Vancouver

Banerjee G, Ambler G, Hostettler IC, Shakeshaft C, Lunawat S, Cohen H et al. Baseline factors associated with early and late death in intracerebral haemorrhage survivors. European Journal of Neurology. 2020 Jul 1;27(7):1257-1263. Epub 2020 Mar 29. doi: 10.1111/ene.14238

Author

Banerjee, G. ; Ambler, G. ; Hostettler, I. C. et al. / Baseline factors associated with early and late death in intracerebral haemorrhage survivors. In: European Journal of Neurology. 2020 ; Vol. 27, No. 7. pp. 1257-1263.

Bibtex

@article{93a2f75006464a8bb40c34fafcf19f3d,
title = "Baseline factors associated with early and late death in intracerebral haemorrhage survivors",
abstract = "Background and purpose: The aim of this study was to determine whether early and late death are associated with different baseline factors in intracerebral haemorrhage (ICH) survivors. Methods: This was a secondary analysis of the multicentre prospective observational CROMIS-2 ICH study. Death was defined as {\textquoteleft}early{\textquoteright} if occurring within 6 months of study entry and {\textquoteleft}late{\textquoteright} if occurring after this time point. Results: In our cohort (n = 1094), there were 306 deaths (per 100 patient-years: absolute event rate, 11.7; 95% confidence intervals, 10.5–13.1); 156 were {\textquoteleft}early{\textquoteright} and 150 {\textquoteleft}late{\textquoteright}. In multivariable analyses, early death was independently associated with age [per year increase; hazard ratio (HR), 1.05, P = 0.003], history of hypertension (HR, 1.89, P = 0.038), pre-event modified Rankin scale score (per point increase; HR, 1.41, P < 0.0001), admission National Institutes of Health Stroke Scale score (per point increase; HR, 1.11, P < 0.0001) and haemorrhage volume >60 mL (HR, 4.08, P < 0.0001). Late death showed independent associations with age (per year increase; HR, 1.04, P = 0.003), pre-event modified Rankin scale score (per point increase; HR, 1.42, P = 0.001), prior anticoagulant use (HR, 2.13, P = 0.028) and the presence of intraventricular extension (HR, 1.73, P = 0.033) in multivariable analyses. In further analyses where time was treated as continuous (rather than dichotomized), the HR of previous cerebral ischaemic events increased with time, whereas HRs for Glasgow Coma Scale score, National Institutes of Health Stroke Scale score and ICH volume decreased over time. Conclusions: We provide new evidence that not all baseline factors associated with early mortality after ICH are associated with mortality after 6 months and that the effects of baseline variables change over time. Our findings could help design better prognostic scores for later death after ICH.",
keywords = "intracerebral haemorrhage, mortality, prognosis",
author = "G. Banerjee and G. Ambler and Hostettler, {I. C.} and C. Shakeshaft and S. Lunawat and H. Cohen and T. Yousry and {Al-Shahi Salman}, R. and Lip, {G. Y.H.} and H. Houlden and Muir, {K. W.} and J{\"a}ger, {H. R.} and Werring, {D. J.} and Louise Shaw and Kirsty Harkness and Jane Sword and {Mohd Nor}, Azlisham and Pankaj Sharma and Deborah Kelly and Frances Harrington and Marc Randall and Matthew Smith and Karim Mahawish and Abduelbaset Elmarim and Bernard Esisi and Claire Cullen and Arumug Nallasivam and Christopher Price and Adrian Barry and Christine Roffe and John Coyle and Ahamad Hassan and Caroline Lovelock and Jonathan Birns and David Cohen and L. Sekaran and Adrian Parry-Jones and Anthea Parry and David Hargroves and Harald Proschel and Prabel Datta and Khaled Darawil and Aravindakshan Manoj and Mathew Burn and Chris Patterson and Elio Giallombardo and Nigel Smyth and Syed Mansoor and Ijaz Anwar and Rachel Marsh and Sissi Ispoglou and Dinesh Chadha and Mathuri Prabhakaran and Sanjeevikumar Meenakishundaram and Janice O'Connell and Jon Scott and Vinodh Krishnamurthy and Prasanna Aghoram and Michael McCormick and Paul O{\textquoteright}Mahony and Martin Cooper and Lillian Choy and Peter Wilkinson and Simon Leach and Sarah Caine and Ilse Burger and Gunaratam Gunathilagan and Paul Guyler and Hedley Emsley and Michelle Davis and Dulka Manawadu and Kath Pasco and Maam Mamun and Robert Luder and Mahmud Sajid and Ijaz Anwar and James Okwera and Julie Staals and Elizabeth Warburton and Kari Saastamoinen and Timothy England and Janet Putterill and Enrico Flossman and Michael Power and Krishna Dani and David Mangion and Appu Suman and John Corrigan and Enas Lawrence and Djamil Vahidassr",
year = "2020",
month = jul,
day = "1",
doi = "10.1111/ene.14238",
language = "English",
volume = "27",
pages = "1257--1263",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Baseline factors associated with early and late death in intracerebral haemorrhage survivors

AU - Banerjee, G.

AU - Ambler, G.

AU - Hostettler, I. C.

AU - Shakeshaft, C.

AU - Lunawat, S.

AU - Cohen, H.

AU - Yousry, T.

AU - Al-Shahi Salman, R.

AU - Lip, G. Y.H.

AU - Houlden, H.

AU - Muir, K. W.

AU - Jäger, H. R.

AU - Werring, D. J.

AU - Shaw, Louise

AU - Harkness, Kirsty

AU - Sword, Jane

AU - Mohd Nor, Azlisham

AU - Sharma, Pankaj

AU - Kelly, Deborah

AU - Harrington, Frances

AU - Randall, Marc

AU - Smith, Matthew

AU - Mahawish, Karim

AU - Elmarim, Abduelbaset

AU - Esisi, Bernard

AU - Cullen, Claire

AU - Nallasivam, Arumug

AU - Price, Christopher

AU - Barry, Adrian

AU - Roffe, Christine

AU - Coyle, John

AU - Hassan, Ahamad

AU - Lovelock, Caroline

AU - Birns, Jonathan

AU - Cohen, David

AU - Sekaran, L.

AU - Parry-Jones, Adrian

AU - Parry, Anthea

AU - Hargroves, David

AU - Proschel, Harald

AU - Datta, Prabel

AU - Darawil, Khaled

AU - Manoj, Aravindakshan

AU - Burn, Mathew

AU - Patterson, Chris

AU - Giallombardo, Elio

AU - Smyth, Nigel

AU - Mansoor, Syed

AU - Anwar, Ijaz

AU - Marsh, Rachel

AU - Ispoglou, Sissi

AU - Chadha, Dinesh

AU - Prabhakaran, Mathuri

AU - Meenakishundaram, Sanjeevikumar

AU - O'Connell, Janice

AU - Scott, Jon

AU - Krishnamurthy, Vinodh

AU - Aghoram, Prasanna

AU - McCormick, Michael

AU - O’Mahony, Paul

AU - Cooper, Martin

AU - Choy, Lillian

AU - Wilkinson, Peter

AU - Leach, Simon

AU - Caine, Sarah

AU - Burger, Ilse

AU - Gunathilagan, Gunaratam

AU - Guyler, Paul

AU - Emsley, Hedley

AU - Davis, Michelle

AU - Manawadu, Dulka

AU - Pasco, Kath

AU - Mamun, Maam

AU - Luder, Robert

AU - Sajid, Mahmud

AU - Anwar, Ijaz

AU - Okwera, James

AU - Staals, Julie

AU - Warburton, Elizabeth

AU - Saastamoinen, Kari

AU - England, Timothy

AU - Putterill, Janet

AU - Flossman, Enrico

AU - Power, Michael

AU - Dani, Krishna

AU - Mangion, David

AU - Suman, Appu

AU - Corrigan, John

AU - Lawrence, Enas

AU - Vahidassr, Djamil

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Background and purpose: The aim of this study was to determine whether early and late death are associated with different baseline factors in intracerebral haemorrhage (ICH) survivors. Methods: This was a secondary analysis of the multicentre prospective observational CROMIS-2 ICH study. Death was defined as ‘early’ if occurring within 6 months of study entry and ‘late’ if occurring after this time point. Results: In our cohort (n = 1094), there were 306 deaths (per 100 patient-years: absolute event rate, 11.7; 95% confidence intervals, 10.5–13.1); 156 were ‘early’ and 150 ‘late’. In multivariable analyses, early death was independently associated with age [per year increase; hazard ratio (HR), 1.05, P = 0.003], history of hypertension (HR, 1.89, P = 0.038), pre-event modified Rankin scale score (per point increase; HR, 1.41, P < 0.0001), admission National Institutes of Health Stroke Scale score (per point increase; HR, 1.11, P < 0.0001) and haemorrhage volume >60 mL (HR, 4.08, P < 0.0001). Late death showed independent associations with age (per year increase; HR, 1.04, P = 0.003), pre-event modified Rankin scale score (per point increase; HR, 1.42, P = 0.001), prior anticoagulant use (HR, 2.13, P = 0.028) and the presence of intraventricular extension (HR, 1.73, P = 0.033) in multivariable analyses. In further analyses where time was treated as continuous (rather than dichotomized), the HR of previous cerebral ischaemic events increased with time, whereas HRs for Glasgow Coma Scale score, National Institutes of Health Stroke Scale score and ICH volume decreased over time. Conclusions: We provide new evidence that not all baseline factors associated with early mortality after ICH are associated with mortality after 6 months and that the effects of baseline variables change over time. Our findings could help design better prognostic scores for later death after ICH.

AB - Background and purpose: The aim of this study was to determine whether early and late death are associated with different baseline factors in intracerebral haemorrhage (ICH) survivors. Methods: This was a secondary analysis of the multicentre prospective observational CROMIS-2 ICH study. Death was defined as ‘early’ if occurring within 6 months of study entry and ‘late’ if occurring after this time point. Results: In our cohort (n = 1094), there were 306 deaths (per 100 patient-years: absolute event rate, 11.7; 95% confidence intervals, 10.5–13.1); 156 were ‘early’ and 150 ‘late’. In multivariable analyses, early death was independently associated with age [per year increase; hazard ratio (HR), 1.05, P = 0.003], history of hypertension (HR, 1.89, P = 0.038), pre-event modified Rankin scale score (per point increase; HR, 1.41, P < 0.0001), admission National Institutes of Health Stroke Scale score (per point increase; HR, 1.11, P < 0.0001) and haemorrhage volume >60 mL (HR, 4.08, P < 0.0001). Late death showed independent associations with age (per year increase; HR, 1.04, P = 0.003), pre-event modified Rankin scale score (per point increase; HR, 1.42, P = 0.001), prior anticoagulant use (HR, 2.13, P = 0.028) and the presence of intraventricular extension (HR, 1.73, P = 0.033) in multivariable analyses. In further analyses where time was treated as continuous (rather than dichotomized), the HR of previous cerebral ischaemic events increased with time, whereas HRs for Glasgow Coma Scale score, National Institutes of Health Stroke Scale score and ICH volume decreased over time. Conclusions: We provide new evidence that not all baseline factors associated with early mortality after ICH are associated with mortality after 6 months and that the effects of baseline variables change over time. Our findings could help design better prognostic scores for later death after ICH.

KW - intracerebral haemorrhage

KW - mortality

KW - prognosis

U2 - 10.1111/ene.14238

DO - 10.1111/ene.14238

M3 - Journal article

C2 - 32223078

AN - SCOPUS:85084219545

VL - 27

SP - 1257

EP - 1263

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 7

ER -