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Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing via laser two-photon polymerisation

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Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing via laser two-photon polymerisation. / Balčiunas, E.; Dreiže, N.; Grubliauskaite, M. et al.
In: Materials, Vol. 12, No. 23, 3932, 27.11.2019.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Balčiunas, E, Dreiže, N, Grubliauskaite, M, Urnikyte, S, Šimoliunas, E, Bukelskiene, V, Valius, M, Baldock, SJ, Hardy, JG & Baltriukiene, D 2019, 'Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing via laser two-photon polymerisation', Materials, vol. 12, no. 23, 3932. https://doi.org/10.3390/ma122333932

APA

Balčiunas, E., Dreiže, N., Grubliauskaite, M., Urnikyte, S., Šimoliunas, E., Bukelskiene, V., Valius, M., Baldock, S. J., Hardy, J. G., & Baltriukiene, D. (2019). Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing via laser two-photon polymerisation. Materials, 12(23), Article 3932. https://doi.org/10.3390/ma122333932

Vancouver

Balčiunas E, Dreiže N, Grubliauskaite M, Urnikyte S, Šimoliunas E, Bukelskiene V et al. Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing via laser two-photon polymerisation. Materials. 2019 Nov 27;12(23):3932. doi: 10.3390/ma122333932

Author

Balčiunas, E. ; Dreiže, N. ; Grubliauskaite, M. et al. / Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing via laser two-photon polymerisation. In: Materials. 2019 ; Vol. 12, No. 23.

Bibtex

@article{55743c87808c42fba6d365718d3a2465,
title = "Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing via laser two-photon polymerisation",
abstract = "Hybrid organometallic polymers are a class of functional materials which can be used to produce structures with sub-micron features via laser two-photon polymerisation. Previous studies demonstrated the relative biocompatibility of Al and Zr containing hybrid organometallic polymers in vitro. However, a deeper understanding of their effects on intracellular processes is needed if a tissue engineering strategy based on these materials is to be envisioned. Herein, primary rat myogenic cells were cultured on spin-coated Al and Zr containing polymer surfaces to investigate how each material affects the viability, adhesion strength, adhesion-associated protein expression, rate of cellular metabolism and collagen secretion. We found that the investigated surfaces supported cellular growth to full confluency. A subsequent MTT assay showed that glass and Zr surfaces led to higher rates of metabolism than did the Al surfaces. A viability assay revealed that all surfaces supported comparable levels of cell viability. Cellular adhesion strength assessment showed an insignificantly stronger relative adhesion after 4 h of culture than after 24 h. The largest amount of collagen was secreted by cells grown on the Al-containing surface. In conclusion, the materials were found to be biocompatible in vitro and have potential for bioengineering applications.",
keywords = "bioactive surfaces, biomaterials, hybrid organometallic polymers, laser two-photon polymerisation, tissue engineering",
author = "E. Bal{\v c}iunas and N. Drei{\v z}e and M. Grubliauskaite and S. Urnikyte and E. {\v S}imoliunas and V. Bukelskiene and M. Valius and S.J. Baldock and J.G. Hardy and D. Baltriukiene",
year = "2019",
month = nov,
day = "27",
doi = "10.3390/ma122333932",
language = "English",
volume = "12",
journal = "Materials",
issn = "1996-1944",
publisher = "MDPI AG",
number = "23",

}

RIS

TY - JOUR

T1 - Biocompatibility investigation of hybrid organometallic polymers for sub-micron 3D printing via laser two-photon polymerisation

AU - Balčiunas, E.

AU - Dreiže, N.

AU - Grubliauskaite, M.

AU - Urnikyte, S.

AU - Šimoliunas, E.

AU - Bukelskiene, V.

AU - Valius, M.

AU - Baldock, S.J.

AU - Hardy, J.G.

AU - Baltriukiene, D.

PY - 2019/11/27

Y1 - 2019/11/27

N2 - Hybrid organometallic polymers are a class of functional materials which can be used to produce structures with sub-micron features via laser two-photon polymerisation. Previous studies demonstrated the relative biocompatibility of Al and Zr containing hybrid organometallic polymers in vitro. However, a deeper understanding of their effects on intracellular processes is needed if a tissue engineering strategy based on these materials is to be envisioned. Herein, primary rat myogenic cells were cultured on spin-coated Al and Zr containing polymer surfaces to investigate how each material affects the viability, adhesion strength, adhesion-associated protein expression, rate of cellular metabolism and collagen secretion. We found that the investigated surfaces supported cellular growth to full confluency. A subsequent MTT assay showed that glass and Zr surfaces led to higher rates of metabolism than did the Al surfaces. A viability assay revealed that all surfaces supported comparable levels of cell viability. Cellular adhesion strength assessment showed an insignificantly stronger relative adhesion after 4 h of culture than after 24 h. The largest amount of collagen was secreted by cells grown on the Al-containing surface. In conclusion, the materials were found to be biocompatible in vitro and have potential for bioengineering applications.

AB - Hybrid organometallic polymers are a class of functional materials which can be used to produce structures with sub-micron features via laser two-photon polymerisation. Previous studies demonstrated the relative biocompatibility of Al and Zr containing hybrid organometallic polymers in vitro. However, a deeper understanding of their effects on intracellular processes is needed if a tissue engineering strategy based on these materials is to be envisioned. Herein, primary rat myogenic cells were cultured on spin-coated Al and Zr containing polymer surfaces to investigate how each material affects the viability, adhesion strength, adhesion-associated protein expression, rate of cellular metabolism and collagen secretion. We found that the investigated surfaces supported cellular growth to full confluency. A subsequent MTT assay showed that glass and Zr surfaces led to higher rates of metabolism than did the Al surfaces. A viability assay revealed that all surfaces supported comparable levels of cell viability. Cellular adhesion strength assessment showed an insignificantly stronger relative adhesion after 4 h of culture than after 24 h. The largest amount of collagen was secreted by cells grown on the Al-containing surface. In conclusion, the materials were found to be biocompatible in vitro and have potential for bioengineering applications.

KW - bioactive surfaces

KW - biomaterials

KW - hybrid organometallic polymers

KW - laser two-photon polymerisation

KW - tissue engineering

U2 - 10.3390/ma122333932

DO - 10.3390/ma122333932

M3 - Journal article

VL - 12

JO - Materials

JF - Materials

SN - 1996-1944

IS - 23

M1 - 3932

ER -