Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Biosurfactants as foaming agents in calcium phosphate bone cements
AU - Cichon, Ewelina
AU - Czechowska, Joanna
AU - Krok-Borkowicz, Malgorzata
AU - Allinson, Sarah
AU - Stepien, Karolina
AU - Smith, Alan
AU - Pamula, Elzbieta
AU - Douglas, Timothy
AU - Zima, Aneta
N1 - This is the author’s version of a work that was accepted for publication in Biomaterials Advances. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biomaterials Advances, 145, 2023 DOI: 10.1016/j.bioadv.2022.213273
PY - 2023/2/28
Y1 - 2023/2/28
N2 - The idea of using biosurfactants to obtain highly porous, foamed calcium phosphate cements (fCPCs) is novel. The popularity of these compounds is mainly attributed to their biological activity such as anticancer or antibacterial properties. In our study, it was investigated how the functionalization of cements, based on α-tricalcium phosphate (α-TCP), with non-ionic biosurfactants such as sucrose ester S0112 and saponin from Quillaja bark affected the physicochemical as well as biological properties of cement-type materials. Foaming with these selected surface active agents led to highly porous fCPCs (open porosity >60 vol%) with compressive strength values ranging from 0.2 to 3.3 MPa and did not influence negatively the bioactive potential of the cements. Results showed that the sucrose ester had a positive effect on all studied cell types (osteosarcoma cell line MG-63 and preosteoblasts MC3T3-E1), while the effect of the saponin differed depending on the origin of the cells (cancerous or non-cancerous). The obtained results shed new light on the use of biosurfactants as additives to CPCs and pave the way for further studies, especially in vivo.
AB - The idea of using biosurfactants to obtain highly porous, foamed calcium phosphate cements (fCPCs) is novel. The popularity of these compounds is mainly attributed to their biological activity such as anticancer or antibacterial properties. In our study, it was investigated how the functionalization of cements, based on α-tricalcium phosphate (α-TCP), with non-ionic biosurfactants such as sucrose ester S0112 and saponin from Quillaja bark affected the physicochemical as well as biological properties of cement-type materials. Foaming with these selected surface active agents led to highly porous fCPCs (open porosity >60 vol%) with compressive strength values ranging from 0.2 to 3.3 MPa and did not influence negatively the bioactive potential of the cements. Results showed that the sucrose ester had a positive effect on all studied cell types (osteosarcoma cell line MG-63 and preosteoblasts MC3T3-E1), while the effect of the saponin differed depending on the origin of the cells (cancerous or non-cancerous). The obtained results shed new light on the use of biosurfactants as additives to CPCs and pave the way for further studies, especially in vivo.
KW - Bone cements
KW - Biosurfactants
KW - Calcium phosphates
KW - Porosity
KW - Nonionic surfactants
U2 - 10.1016/j.bioadv.2022.213273
DO - 10.1016/j.bioadv.2022.213273
M3 - Journal article
VL - 145
JO - Biomaterials Advances
JF - Biomaterials Advances
SN - 2772-9508
M1 - 213273
ER -