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    Rights statement: © 2006 Scutt et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Breast asymmetry and predisposition to breast cancer

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Breast asymmetry and predisposition to breast cancer. / Scutt, Diane; Lancaster, Gillian; Manning, John T.
In: Breast Cancer Research, Vol. 8, No. 2, R14, 20.03.2006.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Scutt, D, Lancaster, G & Manning, JT 2006, 'Breast asymmetry and predisposition to breast cancer', Breast Cancer Research, vol. 8, no. 2, R14. https://doi.org/10.1186/bcr1388

APA

Scutt, D., Lancaster, G., & Manning, J. T. (2006). Breast asymmetry and predisposition to breast cancer. Breast Cancer Research, 8(2), Article R14. https://doi.org/10.1186/bcr1388

Vancouver

Scutt D, Lancaster G, Manning JT. Breast asymmetry and predisposition to breast cancer. Breast Cancer Research. 2006 Mar 20;8(2):R14. doi: 10.1186/bcr1388

Author

Scutt, Diane ; Lancaster, Gillian ; Manning, John T. / Breast asymmetry and predisposition to breast cancer. In: Breast Cancer Research. 2006 ; Vol. 8, No. 2.

Bibtex

@article{ec1bbe5a06974d2fbf173f4734351368,
title = "Breast asymmetry and predisposition to breast cancer",
abstract = "IntroductionIt has been shown in our previous work that breast asymmetry is related to several of the known risk factors for breast cancer, and that patients with diagnosed breast cancer have more breast volume asymmetry, as measured from mammograms, than age-matched healthy women.MethodsIn the present study, we compared the breast asymmetry of women who were free of breast disease at time of mammography, but who had subsequently developed breast cancer, with that of age-matched healthy controls who had remained disease-free to time of the present study. The study group consisted of 252 asymptomatic women who had normal mammography, but went on to develop breast cancer. The control group were 252 age-matched healthy controls whose mammograms were also normal and who remained free of cancer during the study period. Breast volume was calculated from the cranio-caudal mammograms for each group, and the relationships between asymmetry, established risk factors and the presence or absence of breast cancer were explored.ResultsThe group who went on to develop breast cancer had higher breast asymmetry than controls (absolute asymmetry odds ratio 1.50 per 100 ml, confidence interval (CI) 1.10, 2.04; relative asymmetry 1.09, CI 1.01, 1.18), increased incidence of family history of breast cancer, lower age at menarche, later menopause, later first pregnancies and a higher frequency of high risk breast parenchyma types. Conditional logistic regression analysis showed that breast asymmetry, height, family history of breast cancer, age at menarche, parenchyma type and menopausal status were significant independent predictors of breast cancer. When age at menopause was included in the model for the subgroup of post-menopausal women, absolute breast fluctuating asymmetry (FA) and relative breast FA remained significant effects.ConclusionBreast asymmetry was greater in healthy women who later developed breast cancer than in women who did not.",
author = "Diane Scutt and Gillian Lancaster and Manning, {John T}",
note = "{\textcopyright} 2006 Scutt et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2006",
month = mar,
day = "20",
doi = "10.1186/bcr1388",
language = "English",
volume = "8",
journal = "Breast Cancer Research",
issn = "1465-542X",
publisher = "BioMed Central",
number = "2",

}

RIS

TY - JOUR

T1 - Breast asymmetry and predisposition to breast cancer

AU - Scutt, Diane

AU - Lancaster, Gillian

AU - Manning, John T

N1 - © 2006 Scutt et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2006/3/20

Y1 - 2006/3/20

N2 - IntroductionIt has been shown in our previous work that breast asymmetry is related to several of the known risk factors for breast cancer, and that patients with diagnosed breast cancer have more breast volume asymmetry, as measured from mammograms, than age-matched healthy women.MethodsIn the present study, we compared the breast asymmetry of women who were free of breast disease at time of mammography, but who had subsequently developed breast cancer, with that of age-matched healthy controls who had remained disease-free to time of the present study. The study group consisted of 252 asymptomatic women who had normal mammography, but went on to develop breast cancer. The control group were 252 age-matched healthy controls whose mammograms were also normal and who remained free of cancer during the study period. Breast volume was calculated from the cranio-caudal mammograms for each group, and the relationships between asymmetry, established risk factors and the presence or absence of breast cancer were explored.ResultsThe group who went on to develop breast cancer had higher breast asymmetry than controls (absolute asymmetry odds ratio 1.50 per 100 ml, confidence interval (CI) 1.10, 2.04; relative asymmetry 1.09, CI 1.01, 1.18), increased incidence of family history of breast cancer, lower age at menarche, later menopause, later first pregnancies and a higher frequency of high risk breast parenchyma types. Conditional logistic regression analysis showed that breast asymmetry, height, family history of breast cancer, age at menarche, parenchyma type and menopausal status were significant independent predictors of breast cancer. When age at menopause was included in the model for the subgroup of post-menopausal women, absolute breast fluctuating asymmetry (FA) and relative breast FA remained significant effects.ConclusionBreast asymmetry was greater in healthy women who later developed breast cancer than in women who did not.

AB - IntroductionIt has been shown in our previous work that breast asymmetry is related to several of the known risk factors for breast cancer, and that patients with diagnosed breast cancer have more breast volume asymmetry, as measured from mammograms, than age-matched healthy women.MethodsIn the present study, we compared the breast asymmetry of women who were free of breast disease at time of mammography, but who had subsequently developed breast cancer, with that of age-matched healthy controls who had remained disease-free to time of the present study. The study group consisted of 252 asymptomatic women who had normal mammography, but went on to develop breast cancer. The control group were 252 age-matched healthy controls whose mammograms were also normal and who remained free of cancer during the study period. Breast volume was calculated from the cranio-caudal mammograms for each group, and the relationships between asymmetry, established risk factors and the presence or absence of breast cancer were explored.ResultsThe group who went on to develop breast cancer had higher breast asymmetry than controls (absolute asymmetry odds ratio 1.50 per 100 ml, confidence interval (CI) 1.10, 2.04; relative asymmetry 1.09, CI 1.01, 1.18), increased incidence of family history of breast cancer, lower age at menarche, later menopause, later first pregnancies and a higher frequency of high risk breast parenchyma types. Conditional logistic regression analysis showed that breast asymmetry, height, family history of breast cancer, age at menarche, parenchyma type and menopausal status were significant independent predictors of breast cancer. When age at menopause was included in the model for the subgroup of post-menopausal women, absolute breast fluctuating asymmetry (FA) and relative breast FA remained significant effects.ConclusionBreast asymmetry was greater in healthy women who later developed breast cancer than in women who did not.

U2 - 10.1186/bcr1388

DO - 10.1186/bcr1388

M3 - Journal article

C2 - 16563179

VL - 8

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-542X

IS - 2

M1 - R14

ER -