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Calcium catalysed Strecker-type reactions towards α-aminonitriles †

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<mark>Journal publication date</mark>21/04/2025
<mark>Journal</mark>Chemical Communications
Issue number31
Volume61
Number of pages3
Pages (from-to)5739-5741
Publication StatusPublished
Early online date14/03/25
<mark>Original language</mark>English

Abstract

We report an operationally simple calcium catalysed Strecker type reaction for the synthesis of α-aminonitriles from readily available N, O-acetals. The reaction is tolerant to a wide range of useful functional groups, including heterocycles, and provides the product in good to excellent yields. Additionally, the reaction does not require the need for anhydrous or air-free conditions, making it a suitable candidate for high throughput experimentation.