Final published version
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Calcium catalysed Strecker-type reactions towards α-aminonitriles †
AU - Basson, Ashley J.
AU - Cameron, Michael P.
AU - McLaughlin, Mark G.
PY - 2025/4/21
Y1 - 2025/4/21
N2 - We report an operationally simple calcium catalysed Strecker type reaction for the synthesis of α-aminonitriles from readily available N, O-acetals. The reaction is tolerant to a wide range of useful functional groups, including heterocycles, and provides the product in good to excellent yields. Additionally, the reaction does not require the need for anhydrous or air-free conditions, making it a suitable candidate for high throughput experimentation.
AB - We report an operationally simple calcium catalysed Strecker type reaction for the synthesis of α-aminonitriles from readily available N, O-acetals. The reaction is tolerant to a wide range of useful functional groups, including heterocycles, and provides the product in good to excellent yields. Additionally, the reaction does not require the need for anhydrous or air-free conditions, making it a suitable candidate for high throughput experimentation.
U2 - 10.1039/d5cc00539f
DO - 10.1039/d5cc00539f
M3 - Journal article
VL - 61
SP - 5739
EP - 5741
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 31
ER -