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CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading

Research output: Contribution to journalJournal articlepeer-review

Published
  • H. Ding
  • L. Wu
  • T. Guo
  • Z. Zhang
  • B.M. Garba
  • G. Gao
  • S. He
  • W. Zhang
  • Y. Chen
  • Y. Lin
  • H. Liu
  • J. Anwar
  • J. Zhang
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<mark>Journal publication date</mark>3/07/2019
<mark>Journal</mark>Crystal Growth and Design
Issue number7
Volume19
Number of pages7
Pages (from-to)3888-3894
Publication StatusPublished
Early online date31/05/19
<mark>Original language</mark>English

Abstract

Transformation of a dense metal-organic framework (MOF) to a highly porous form can radically improve its applications in drug loading. In this study, an environmentally friendly synthesis of potassium acetate γ-cyclodextrin metal-organic framework (γ-CD-MOF) in water was identified as a dense crystal form. Importantly, the molecular arrangement of the dense γ-CD-MOF was confirmed by single crystal X-ray diffraction and other characterizations. If the dense γ-CD-MOF was directly dried after separation from the mother solution, it is incapable of loading a model drug. However, the fresh dense crystal could be transformed into a highly porous form by introducing ethanol. The crystal transformation was demonstrated by enhanced drug loading capability and characterizations of powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), and the N2 adsorption isotherm. In all, the crystal transformation from dense to highly porous form could significantly facilitate the applications of γ-CD-MOFs in drug loading and other potential fields.