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CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading

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CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading. / Ding, H.; Wu, L.; Guo, T. et al.
In: Crystal Growth and Design, Vol. 19, No. 7, 03.07.2019, p. 3888-3894.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Ding, H, Wu, L, Guo, T, Zhang, Z, Garba, BM, Gao, G, He, S, Zhang, W, Chen, Y, Lin, Y, Liu, H, Anwar, J & Zhang, J 2019, 'CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading', Crystal Growth and Design, vol. 19, no. 7, pp. 3888-3894. https://doi.org/10.1021/acs.cgd.9b00319

APA

Ding, H., Wu, L., Guo, T., Zhang, Z., Garba, B. M., Gao, G., He, S., Zhang, W., Chen, Y., Lin, Y., Liu, H., Anwar, J., & Zhang, J. (2019). CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading. Crystal Growth and Design, 19(7), 3888-3894. https://doi.org/10.1021/acs.cgd.9b00319

Vancouver

Ding H, Wu L, Guo T, Zhang Z, Garba BM, Gao G et al. CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading. Crystal Growth and Design. 2019 Jul 3;19(7):3888-3894. Epub 2019 May 31. doi: 10.1021/acs.cgd.9b00319

Author

Ding, H. ; Wu, L. ; Guo, T. et al. / CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading. In: Crystal Growth and Design. 2019 ; Vol. 19, No. 7. pp. 3888-3894.

Bibtex

@article{9e1cddcd43c54e7295e9067d4c60f781,
title = "CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading",
abstract = "Transformation of a dense metal-organic framework (MOF) to a highly porous form can radically improve its applications in drug loading. In this study, an environmentally friendly synthesis of potassium acetate γ-cyclodextrin metal-organic framework (γ-CD-MOF) in water was identified as a dense crystal form. Importantly, the molecular arrangement of the dense γ-CD-MOF was confirmed by single crystal X-ray diffraction and other characterizations. If the dense γ-CD-MOF was directly dried after separation from the mother solution, it is incapable of loading a model drug. However, the fresh dense crystal could be transformed into a highly porous form by introducing ethanol. The crystal transformation was demonstrated by enhanced drug loading capability and characterizations of powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), and the N2 adsorption isotherm. In all, the crystal transformation from dense to highly porous form could significantly facilitate the applications of γ-CD-MOFs in drug loading and other potential fields.",
keywords = "Crystalline materials, Organometallics, Potassium compounds, Single crystals, X ray diffraction, X ray scattering, Crystal transformation, Environmentally friendly synthesis, Gamma-cyclodextrin, Metal organic framework, Molecular arrangements, Potassium acetate, Powder X-ray diffraction (pXRD), Single crystal x-ray diffraction, Gamma rays",
author = "H. Ding and L. Wu and T. Guo and Z. Zhang and B.M. Garba and G. Gao and S. He and W. Zhang and Y. Chen and Y. Lin and H. Liu and J. Anwar and J. Zhang",
year = "2019",
month = jul,
day = "3",
doi = "10.1021/acs.cgd.9b00319",
language = "English",
volume = "19",
pages = "3888--3894",
journal = "Crystal Growth and Design",
issn = "1528-7483",
publisher = "American Chemical Society",
number = "7",

}

RIS

TY - JOUR

T1 - CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading

AU - Ding, H.

AU - Wu, L.

AU - Guo, T.

AU - Zhang, Z.

AU - Garba, B.M.

AU - Gao, G.

AU - He, S.

AU - Zhang, W.

AU - Chen, Y.

AU - Lin, Y.

AU - Liu, H.

AU - Anwar, J.

AU - Zhang, J.

PY - 2019/7/3

Y1 - 2019/7/3

N2 - Transformation of a dense metal-organic framework (MOF) to a highly porous form can radically improve its applications in drug loading. In this study, an environmentally friendly synthesis of potassium acetate γ-cyclodextrin metal-organic framework (γ-CD-MOF) in water was identified as a dense crystal form. Importantly, the molecular arrangement of the dense γ-CD-MOF was confirmed by single crystal X-ray diffraction and other characterizations. If the dense γ-CD-MOF was directly dried after separation from the mother solution, it is incapable of loading a model drug. However, the fresh dense crystal could be transformed into a highly porous form by introducing ethanol. The crystal transformation was demonstrated by enhanced drug loading capability and characterizations of powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), and the N2 adsorption isotherm. In all, the crystal transformation from dense to highly porous form could significantly facilitate the applications of γ-CD-MOFs in drug loading and other potential fields.

AB - Transformation of a dense metal-organic framework (MOF) to a highly porous form can radically improve its applications in drug loading. In this study, an environmentally friendly synthesis of potassium acetate γ-cyclodextrin metal-organic framework (γ-CD-MOF) in water was identified as a dense crystal form. Importantly, the molecular arrangement of the dense γ-CD-MOF was confirmed by single crystal X-ray diffraction and other characterizations. If the dense γ-CD-MOF was directly dried after separation from the mother solution, it is incapable of loading a model drug. However, the fresh dense crystal could be transformed into a highly porous form by introducing ethanol. The crystal transformation was demonstrated by enhanced drug loading capability and characterizations of powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), and the N2 adsorption isotherm. In all, the crystal transformation from dense to highly porous form could significantly facilitate the applications of γ-CD-MOFs in drug loading and other potential fields.

KW - Crystalline materials

KW - Organometallics

KW - Potassium compounds

KW - Single crystals

KW - X ray diffraction

KW - X ray scattering

KW - Crystal transformation

KW - Environmentally friendly synthesis

KW - Gamma-cyclodextrin

KW - Metal organic framework

KW - Molecular arrangements

KW - Potassium acetate

KW - Powder X-ray diffraction (pXRD)

KW - Single crystal x-ray diffraction

KW - Gamma rays

U2 - 10.1021/acs.cgd.9b00319

DO - 10.1021/acs.cgd.9b00319

M3 - Journal article

VL - 19

SP - 3888

EP - 3894

JO - Crystal Growth and Design

JF - Crystal Growth and Design

SN - 1528-7483

IS - 7

ER -