Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - CD-MOFs Crystal Transformation from Dense to Highly Porous Form for Efficient Drug Loading
AU - Ding, H.
AU - Wu, L.
AU - Guo, T.
AU - Zhang, Z.
AU - Garba, B.M.
AU - Gao, G.
AU - He, S.
AU - Zhang, W.
AU - Chen, Y.
AU - Lin, Y.
AU - Liu, H.
AU - Anwar, J.
AU - Zhang, J.
PY - 2019/7/3
Y1 - 2019/7/3
N2 - Transformation of a dense metal-organic framework (MOF) to a highly porous form can radically improve its applications in drug loading. In this study, an environmentally friendly synthesis of potassium acetate γ-cyclodextrin metal-organic framework (γ-CD-MOF) in water was identified as a dense crystal form. Importantly, the molecular arrangement of the dense γ-CD-MOF was confirmed by single crystal X-ray diffraction and other characterizations. If the dense γ-CD-MOF was directly dried after separation from the mother solution, it is incapable of loading a model drug. However, the fresh dense crystal could be transformed into a highly porous form by introducing ethanol. The crystal transformation was demonstrated by enhanced drug loading capability and characterizations of powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), and the N2 adsorption isotherm. In all, the crystal transformation from dense to highly porous form could significantly facilitate the applications of γ-CD-MOFs in drug loading and other potential fields.
AB - Transformation of a dense metal-organic framework (MOF) to a highly porous form can radically improve its applications in drug loading. In this study, an environmentally friendly synthesis of potassium acetate γ-cyclodextrin metal-organic framework (γ-CD-MOF) in water was identified as a dense crystal form. Importantly, the molecular arrangement of the dense γ-CD-MOF was confirmed by single crystal X-ray diffraction and other characterizations. If the dense γ-CD-MOF was directly dried after separation from the mother solution, it is incapable of loading a model drug. However, the fresh dense crystal could be transformed into a highly porous form by introducing ethanol. The crystal transformation was demonstrated by enhanced drug loading capability and characterizations of powder X-ray diffraction (PXRD), small-angle X-ray scattering (SAXS), and the N2 adsorption isotherm. In all, the crystal transformation from dense to highly porous form could significantly facilitate the applications of γ-CD-MOFs in drug loading and other potential fields.
KW - Crystalline materials
KW - Organometallics
KW - Potassium compounds
KW - Single crystals
KW - X ray diffraction
KW - X ray scattering
KW - Crystal transformation
KW - Environmentally friendly synthesis
KW - Gamma-cyclodextrin
KW - Metal organic framework
KW - Molecular arrangements
KW - Potassium acetate
KW - Powder X-ray diffraction (pXRD)
KW - Single crystal x-ray diffraction
KW - Gamma rays
U2 - 10.1021/acs.cgd.9b00319
DO - 10.1021/acs.cgd.9b00319
M3 - Journal article
VL - 19
SP - 3888
EP - 3894
JO - Crystal Growth and Design
JF - Crystal Growth and Design
SN - 1528-7483
IS - 7
ER -