Final published version
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Cerebellar Volume and Disease Staging in Parkinson's Disease
T2 - An ENIGMA‐PD Study
AU - the ENIGMA‐Parkinson's Study
AU - Kerestes, Rebecca
AU - Laansma, Max A.
AU - Owens‐Walton, Conor
AU - Perry, Andrew
AU - van Heese, Eva M.
AU - Al‐Bachari, Sarah
AU - Anderson, Tim J.
AU - Assogna, Francesca
AU - Aventurato, Ítalo K.
AU - van Balkom, Tim D.
AU - Berendse, Henk W.
AU - van den Berg, Kevin R.E.
AU - Betts, Rebecca
AU - Brioschi, Ricardo
AU - Carr, Jonathan
AU - Cendes, Fernando
AU - Clark, Lyles R.
AU - Dalrymple‐Alford, John C.
AU - Dirkx, Michiel F.
AU - Druzgal, Jason
AU - Durrant, Helena
AU - Emsley, Hedley C.A.
AU - Garraux, Gaëtan
AU - Haroon, Hamied A.
AU - Helmich, Rick C.
AU - van den Heuvel, Odile A.
AU - João, Rafael B.
AU - Johansson, Martin E.
AU - Khachatryan, Samson G.
AU - Lochner, Christine
AU - McMillan, Corey T.
AU - Melzer, Tracy R.
AU - Mosley, Philip E.
AU - Newman, Benjamin
AU - Opriessnig, Peter
AU - Parkes, Laura M.
AU - Pellicano, Clelia
AU - Piras, Fabrizio
AU - Pitcher, Toni L.
AU - Poston, Kathleen L.
AU - Rango, Mario
AU - Roos, Annerine
AU - Rummel, Christian
AU - Schmidt, Reinhold
AU - Schwingenschuh, Petra
AU - Silva, Lucas S.
AU - Smith, Viktorija
AU - Squarcina, Letizia
AU - Stein, Dan J.
AU - Thompson, Paul M.
PY - 2023/12/31
Y1 - 2023/12/31
N2 - BACKGROUND: Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated.OBJECTIVE: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.METHODS: Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated.RESULTS: Overall, people with PD had a regionally smaller posterior lobe (d max = -0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (d max = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (d max = -0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = -0.17). CONCLUSIONS: We provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
AB - BACKGROUND: Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated.OBJECTIVE: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.METHODS: Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated.RESULTS: Overall, people with PD had a regionally smaller posterior lobe (d max = -0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (d max = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (d max = -0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = -0.17). CONCLUSIONS: We provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
KW - cerebellum
KW - MRI
KW - disease staging
KW - Parkinson's disease
U2 - 10.1002/mds.29611
DO - 10.1002/mds.29611
M3 - Journal article
C2 - 37964373
VL - 38
SP - 2269
EP - 2281
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 12
ER -