TY - JOUR

T1 - Childhood Adversity and Borderline Personality Disorder

T2 - A Meta-Analysis

AU - Porter, Carly

AU - Palmier-Claus, Jasper

AU - Branitsky, Alison

AU - Mansell, Warren

AU - Warwick, Helen

AU - Varese, Filippo

N1 - This is the peer reviewed version of the following article: Porter, C, Palmier‐Claus, J, Branitsky, A, Mansell, W, Warwick, H, Varese, F. (2019) Childhood adversity and borderline personality disorder: a meta‐analysis. Acta Psychiatrica Scandinavica. doi: 10.1111/acps.13118 which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1111/acps.13118 This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Objective: The aim of this meta-analysis was to better understand the magnitude and consistency of the association between childhood adversity and borderline personality disorder (BPD) across case-control, epidemiological and prospective cohort studies. Method: Following the review protocol (reference: CRD42017075179), search terms pertaining to adversity and BPD, were entered into three search engines. Random effects meta-analysis synthesised the size and consistency of the effects. Results: 97 studies compared BPD to non-clinical (k = 40) and clinical (k = 70) controls. Meta-analysis of case control studies indicated that individuals with BPD are 13.91 (95% CI 11.11-17.43) times more likely to report childhood adversity than non-clinical controls. This effect was smaller when considering retrospective cohort (OR: 2.59; 95% CI .93-7.30) and epidemiological (OR: 2.56, 95% CI 1.24-5.30) studies. Findings were significant across adversity subtypes with emotional abuse (OR: 38.11, 95% CI: 25.99-55.88) and neglect (OR: 17.73, 95% CI=13.01-24.17) demonstrating the largest effects. Individuals with BPD were 3.15 (95% CI 2.62-3.79) times more likely to report childhood adversity than other psychiatric groups. Conclusions: This meta-analysis corroborates theoretical proposals that exposure to adverse life experiences is associated with BPD. It highlights the importance of considering childhood adversity when treating people diagnosed with BPD.

AB - Objective: The aim of this meta-analysis was to better understand the magnitude and consistency of the association between childhood adversity and borderline personality disorder (BPD) across case-control, epidemiological and prospective cohort studies. Method: Following the review protocol (reference: CRD42017075179), search terms pertaining to adversity and BPD, were entered into three search engines. Random effects meta-analysis synthesised the size and consistency of the effects. Results: 97 studies compared BPD to non-clinical (k = 40) and clinical (k = 70) controls. Meta-analysis of case control studies indicated that individuals with BPD are 13.91 (95% CI 11.11-17.43) times more likely to report childhood adversity than non-clinical controls. This effect was smaller when considering retrospective cohort (OR: 2.59; 95% CI .93-7.30) and epidemiological (OR: 2.56, 95% CI 1.24-5.30) studies. Findings were significant across adversity subtypes with emotional abuse (OR: 38.11, 95% CI: 25.99-55.88) and neglect (OR: 17.73, 95% CI=13.01-24.17) demonstrating the largest effects. Individuals with BPD were 3.15 (95% CI 2.62-3.79) times more likely to report childhood adversity than other psychiatric groups. Conclusions: This meta-analysis corroborates theoretical proposals that exposure to adverse life experiences is associated with BPD. It highlights the importance of considering childhood adversity when treating people diagnosed with BPD.

U2 - 10.1111/acps.13118

DO - 10.1111/acps.13118

M3 - Journal article

VL - 141

SP - 6

EP - 20

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 1

ER -