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Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

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Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. / Carare, Roxana O.; Aldea, Roxana; Agarwal, Nivedita et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 12, No. 1, e12053, 03.08.2020.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Carare, RO, Aldea, R, Agarwal, N, Bacskai, BJ, Bechman, I, Boche, D, Bu, G, Bulters, D, Clemens, A, Counts, SE, de Leon, M, Eide, PK, Fossati, S, Greenberg, SM, Hamel, E, Hawkes, CA, Koronyo-Hamaoui, M, Hainsworth, AH, Holtzman, D, Ihara, M, Jefferson, A, Kalaria, RN, Kipps, CM, Kanninen, KM, Leinonen, V, McLaurin, JA, Miners, S, Malm, T, Nicoll, JAR, Piazza, F, Paul, G, Rich, SM, Saito, S, Shih, A, Scholtzova, H, Snyder, H, Snyder, P, Thormodsson, FR, van Veluw, SJ, Weller, RO, Werring, DJ, Wilcock, D, Wilson, MR, Zlokovic, BV & Verma, A 2020, 'Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 12, no. 1, e12053. https://doi.org/10.1002/dad2.12053

APA

Carare, R. O., Aldea, R., Agarwal, N., Bacskai, B. J., Bechman, I., Boche, D., Bu, G., Bulters, D., Clemens, A., Counts, S. E., de Leon, M., Eide, P. K., Fossati, S., Greenberg, S. M., Hamel, E., Hawkes, C. A., Koronyo-Hamaoui, M., Hainsworth, A. H., Holtzman, D., ... Verma, A. (2020). Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 12(1), Article e12053. https://doi.org/10.1002/dad2.12053

Vancouver

Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2020 Aug 3;12(1):e12053. doi: 10.1002/dad2.12053

Author

Carare, Roxana O. ; Aldea, Roxana ; Agarwal, Nivedita et al. / Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA) : Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2020 ; Vol. 12, No. 1.

Bibtex

@article{03af4076fff24550b53a48c0ebfd7955,
title = "Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy",
abstract = "Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri-arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.",
keywords = "cerebrospinal fluid, clearance, interstitial fluid, IPAD, ISTAART",
author = "Carare, {Roxana O.} and Roxana Aldea and Nivedita Agarwal and Bacskai, {Brian J.} and Ingo Bechman and Delphine Boche and Guojun Bu and Diederik Bulters and Alt Clemens and Counts, {Scott E.} and {de Leon}, Mony and Eide, {Per K.} and Silvia Fossati and Greenberg, {Steven M.} and Edith Hamel and Hawkes, {Cheryl A.} and Maya Koronyo-Hamaoui and Hainsworth, {Atticus H.} and David Holtzman and Masafumi Ihara and Angela Jefferson and Kalaria, {Raj N.} and Kipps, {Christopher M.} and Kanninen, {Katja M.} and Ville Leinonen and McLaurin, {Jo Anne} and Scott Miners and Tarja Malm and Nicoll, {James A.R.} and Fabrizio Piazza and Gesine Paul and Rich, {Steven M.} and Satoshi Saito and Andy Shih and Henrieta Scholtzova and Heather Snyder and Peter Snyder and Thormodsson, {Finnbogi Rutur} and {van Veluw}, {Susanne J.} and Weller, {Roy O.} and Werring, {David J.} and Donna Wilcock and Wilson, {Mark R.} and Zlokovic, {Berislav V.} and Ajay Verma",
year = "2020",
month = aug,
day = "3",
doi = "10.1002/dad2.12053",
language = "English",
volume = "12",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "John Wiley & Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)

T2 - Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

AU - Carare, Roxana O.

AU - Aldea, Roxana

AU - Agarwal, Nivedita

AU - Bacskai, Brian J.

AU - Bechman, Ingo

AU - Boche, Delphine

AU - Bu, Guojun

AU - Bulters, Diederik

AU - Clemens, Alt

AU - Counts, Scott E.

AU - de Leon, Mony

AU - Eide, Per K.

AU - Fossati, Silvia

AU - Greenberg, Steven M.

AU - Hamel, Edith

AU - Hawkes, Cheryl A.

AU - Koronyo-Hamaoui, Maya

AU - Hainsworth, Atticus H.

AU - Holtzman, David

AU - Ihara, Masafumi

AU - Jefferson, Angela

AU - Kalaria, Raj N.

AU - Kipps, Christopher M.

AU - Kanninen, Katja M.

AU - Leinonen, Ville

AU - McLaurin, Jo Anne

AU - Miners, Scott

AU - Malm, Tarja

AU - Nicoll, James A.R.

AU - Piazza, Fabrizio

AU - Paul, Gesine

AU - Rich, Steven M.

AU - Saito, Satoshi

AU - Shih, Andy

AU - Scholtzova, Henrieta

AU - Snyder, Heather

AU - Snyder, Peter

AU - Thormodsson, Finnbogi Rutur

AU - van Veluw, Susanne J.

AU - Weller, Roy O.

AU - Werring, David J.

AU - Wilcock, Donna

AU - Wilson, Mark R.

AU - Zlokovic, Berislav V.

AU - Verma, Ajay

PY - 2020/8/3

Y1 - 2020/8/3

N2 - Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri-arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.

AB - Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri-arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.

KW - cerebrospinal fluid

KW - clearance

KW - interstitial fluid

KW - IPAD

KW - ISTAART

U2 - 10.1002/dad2.12053

DO - 10.1002/dad2.12053

M3 - Journal article

AN - SCOPUS:85096442319

VL - 12

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

IS - 1

M1 - e12053

ER -