Home > Research > Publications & Outputs > Clearance of interstitial fluid (ISF) and CSF (...

Research

Links

Text available via DOI:

  • https://doi.org/10.1002/alz.13512

    Final published version

    Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Keywords

View graph of relations

Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. / Kelly, Louise; Brown, Christopher; Michalik, Daniel et al.
In: Alzheimer's and Dementia : the journal of the Alzheimer's Association, Vol. 20, No. 2, 21.02.2024, p. 1421-1435.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kelly, L, Brown, C, Michalik, D, Hawkes, CA, Aldea, R, Agarwal, N, Salib, R, Alzetani, A, Ethell, DW, Counts, SE, de Leon, M, Fossati, S, Koronyo‐Hamaoui, M, Piazza, F, Rich, SA, Wolters, FJ, Snyder, H, Ismail, O, Elahi, F, Proulx, ST, Verma, A, Wunderlich, H, Haack, M, Dodart, JC, Mazer, N & Carare, RO 2024, 'Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy', Alzheimer's and Dementia : the journal of the Alzheimer's Association, vol. 20, no. 2, pp. 1421-1435. https://doi.org/10.1002/alz.13512

APA

Kelly, L., Brown, C., Michalik, D., Hawkes, C. A., Aldea, R., Agarwal, N., Salib, R., Alzetani, A., Ethell, D. W., Counts, S. E., de Leon, M., Fossati, S., Koronyo‐Hamaoui, M., Piazza, F., Rich, S. A., Wolters, F. J., Snyder, H., Ismail, O., Elahi, F., ... Carare, R. O. (2024). Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimer's and Dementia : the journal of the Alzheimer's Association, 20(2), 1421-1435. https://doi.org/10.1002/alz.13512

Vancouver

Kelly L, Brown C, Michalik D, Hawkes CA, Aldea R, Agarwal N et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimer's and Dementia : the journal of the Alzheimer's Association. 2024 Feb 21;20(2):1421-1435. Epub 2023 Oct 28. doi: 10.1002/alz.13512

Author

Kelly, Louise ; Brown, Christopher ; Michalik, Daniel et al. / Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. In: Alzheimer's and Dementia : the journal of the Alzheimer's Association. 2024 ; Vol. 20, No. 2. pp. 1421-1435.

Bibtex

@article{c1f33a27c4ee42abbac3fb28f0426308,
title = "Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy",
abstract = "This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age‐related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid‐related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA‐related inflammation (CAA‐ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.",
keywords = "ISTAART, interstitial fluid, cerebrospinal fluid, ARIA, amyloid, IPAD, clearance",
author = "Louise Kelly and Christopher Brown and Daniel Michalik and Hawkes, {Cheryl A.} and Roxana Aldea and Nivedita Agarwal and Rami Salib and Aiman Alzetani and Ethell, {Douglas W} and Counts, {Scott E.} and {de Leon}, Mony and Silvia Fossati and Maya Koronyo‐Hamaoui and Fabrizio Piazza and Rich, {Steven A.} and Wolters, {Frank J.} and Heather Snyder and Ozama Ismail and Fanny Elahi and Proulx, {Steven T.} and Ajay Verma and Hilary Wunderlich and Mareike Haack and Dodart, {Jean Cosme} and Norman Mazer and Carare, {Roxana O.}",
year = "2024",
month = feb,
day = "21",
doi = "10.1002/alz.13512",
language = "English",
volume = "20",
pages = "1421--1435",
journal = "Alzheimer's and Dementia : the journal of the Alzheimer's Association",
issn = "1552-5260",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy

AU - Kelly, Louise

AU - Brown, Christopher

AU - Michalik, Daniel

AU - Hawkes, Cheryl A.

AU - Aldea, Roxana

AU - Agarwal, Nivedita

AU - Salib, Rami

AU - Alzetani, Aiman

AU - Ethell, Douglas W

AU - Counts, Scott E.

AU - de Leon, Mony

AU - Fossati, Silvia

AU - Koronyo‐Hamaoui, Maya

AU - Piazza, Fabrizio

AU - Rich, Steven A.

AU - Wolters, Frank J.

AU - Snyder, Heather

AU - Ismail, Ozama

AU - Elahi, Fanny

AU - Proulx, Steven T.

AU - Verma, Ajay

AU - Wunderlich, Hilary

AU - Haack, Mareike

AU - Dodart, Jean Cosme

AU - Mazer, Norman

AU - Carare, Roxana O.

PY - 2024/2/21

Y1 - 2024/2/21

N2 - This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age‐related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid‐related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA‐related inflammation (CAA‐ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.

AB - This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age‐related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid‐related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA‐related inflammation (CAA‐ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.

KW - ISTAART

KW - interstitial fluid

KW - cerebrospinal fluid

KW - ARIA

KW - amyloid

KW - IPAD

KW - clearance

U2 - 10.1002/alz.13512

DO - 10.1002/alz.13512

M3 - Journal article

VL - 20

SP - 1421

EP - 1435

JO - Alzheimer's and Dementia : the journal of the Alzheimer's Association

JF - Alzheimer's and Dementia : the journal of the Alzheimer's Association

SN - 1552-5260

IS - 2

ER -