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Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans. / Kim, Ban-seok; Alcantara, Alfredo; Moon, Je-Hyun et al.
In: International Journal of Molecular Sciences, Vol. 24, No. 16, 12640, 10.08.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kim, B, Alcantara, A, Moon, J-H, Higashitani, A, Higashitani, N, Etheridge, T, Szewczyk, NJ, Deane, C, Gaffney, C, Higashibata, A, Hashizume, T, Yoon, K & Lee, J 2023, 'Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans', International Journal of Molecular Sciences, vol. 24, no. 16, 12640. https://doi.org/10.3390/ijms241612640

APA

Kim, B., Alcantara, A., Moon, J-H., Higashitani, A., Higashitani, N., Etheridge, T., Szewczyk, N. J., Deane, C., Gaffney, C., Higashibata, A., Hashizume, T., Yoon, K., & Lee, J. (2023). Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans. International Journal of Molecular Sciences, 24(16), Article 12640. https://doi.org/10.3390/ijms241612640

Vancouver

Kim B, Alcantara A, Moon J-H, Higashitani A, Higashitani N, Etheridge T et al. Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans. International Journal of Molecular Sciences. 2023 Aug 10;24(16):12640. doi: 10.3390/ijms241612640

Author

Kim, Ban-seok ; Alcantara, Alfredo ; Moon, Je-Hyun et al. / Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 16.

Bibtex

@article{34d9b359c1b64f5b84c3f8e13fa2cf04,
title = "Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans",
abstract = "While spaceflight is becoming more common than before, the hazards spaceflight and space microgravity pose to the human body remain relatively unexplored. Astronauts experience muscle atrophy after spaceflight, but the exact reasons for this and solutions are unknown. Here, we take advantage of the nematode C. elegans to understand the effects of space microgravity on worm body wall muscle. We found that space microgravity induces muscle atrophy in C. elegans from two independent spaceflight missions. As a comparison to spaceflight-induced muscle atrophy, we assessed the effects of acute nutritional deprivation and muscle disuse on C. elegans muscle cells. We found that these two factors also induce muscle atrophy in the nematode. Finally, we identified clp-4, which encodes a calpain protease that promotes muscle atrophy. Mutants of clp-4 suppress starvation-induced muscle atrophy. Such comparative analyses of different factors causing muscle atrophy in C. elegans could provide a way to identify novel genetic factors regulating space microgravity-induced muscle atrophy.",
keywords = "C. elegans, space, microgravity, muscle atrophy, calpain",
author = "Ban-seok Kim and Alfredo Alcantara and Je-Hyun Moon and Atsushi Higashitani and Nahoko Higashitani and Tim Etheridge and Szewczyk, {Nathaniel J} and Colleen Deane and Christopher Gaffney and Akira Higashibata and Toko Hashizume and Kyoung-hye Yoon and Jin Lee",
year = "2023",
month = aug,
day = "10",
doi = "10.3390/ijms241612640",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "MDPI AG",
number = "16",

}

RIS

TY - JOUR

T1 - Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans

AU - Kim, Ban-seok

AU - Alcantara, Alfredo

AU - Moon, Je-Hyun

AU - Higashitani, Atsushi

AU - Higashitani, Nahoko

AU - Etheridge, Tim

AU - Szewczyk, Nathaniel J

AU - Deane, Colleen

AU - Gaffney, Christopher

AU - Higashibata, Akira

AU - Hashizume, Toko

AU - Yoon, Kyoung-hye

AU - Lee, Jin

PY - 2023/8/10

Y1 - 2023/8/10

N2 - While spaceflight is becoming more common than before, the hazards spaceflight and space microgravity pose to the human body remain relatively unexplored. Astronauts experience muscle atrophy after spaceflight, but the exact reasons for this and solutions are unknown. Here, we take advantage of the nematode C. elegans to understand the effects of space microgravity on worm body wall muscle. We found that space microgravity induces muscle atrophy in C. elegans from two independent spaceflight missions. As a comparison to spaceflight-induced muscle atrophy, we assessed the effects of acute nutritional deprivation and muscle disuse on C. elegans muscle cells. We found that these two factors also induce muscle atrophy in the nematode. Finally, we identified clp-4, which encodes a calpain protease that promotes muscle atrophy. Mutants of clp-4 suppress starvation-induced muscle atrophy. Such comparative analyses of different factors causing muscle atrophy in C. elegans could provide a way to identify novel genetic factors regulating space microgravity-induced muscle atrophy.

AB - While spaceflight is becoming more common than before, the hazards spaceflight and space microgravity pose to the human body remain relatively unexplored. Astronauts experience muscle atrophy after spaceflight, but the exact reasons for this and solutions are unknown. Here, we take advantage of the nematode C. elegans to understand the effects of space microgravity on worm body wall muscle. We found that space microgravity induces muscle atrophy in C. elegans from two independent spaceflight missions. As a comparison to spaceflight-induced muscle atrophy, we assessed the effects of acute nutritional deprivation and muscle disuse on C. elegans muscle cells. We found that these two factors also induce muscle atrophy in the nematode. Finally, we identified clp-4, which encodes a calpain protease that promotes muscle atrophy. Mutants of clp-4 suppress starvation-induced muscle atrophy. Such comparative analyses of different factors causing muscle atrophy in C. elegans could provide a way to identify novel genetic factors regulating space microgravity-induced muscle atrophy.

KW - C. elegans

KW - space

KW - microgravity

KW - muscle atrophy

KW - calpain

U2 - 10.3390/ijms241612640

DO - 10.3390/ijms241612640

M3 - Journal article

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 16

M1 - 12640

ER -