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  • Williams_2014_NFkB_Model_Review

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Computational models of the NF-κB signalling pathway

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<mark>Journal publication date</mark>29/09/2014
<mark>Journal</mark>Computation
Issue number4
Volume2
Number of pages28
Pages (from-to)131-158
Publication StatusPublished
<mark>Original language</mark>English

Abstract

In this review article, we discuss the current state of computational modelling of the nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-κB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-κB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-κB control.

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Copyright 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license(http://creativecommons.org/licenses/by/4.0/).