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Computational models of the NF-κB signalling pathway

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Computational models of the NF-κB signalling pathway. / Williams, Richard; Timmis, Jon; Qwarnstrom, Eva E.

In: Computation, Vol. 2, No. 4, 29.09.2014, p. 131-158.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Williams, R, Timmis, J & Qwarnstrom, EE 2014, 'Computational models of the NF-κB signalling pathway', Computation, vol. 2, no. 4, pp. 131-158. https://doi.org/10.3390/computation2040131

APA

Williams, R., Timmis, J., & Qwarnstrom, E. E. (2014). Computational models of the NF-κB signalling pathway. Computation, 2(4), 131-158. https://doi.org/10.3390/computation2040131

Vancouver

Williams R, Timmis J, Qwarnstrom EE. Computational models of the NF-κB signalling pathway. Computation. 2014 Sep 29;2(4):131-158. doi: 10.3390/computation2040131

Author

Williams, Richard ; Timmis, Jon ; Qwarnstrom, Eva E. / Computational models of the NF-κB signalling pathway. In: Computation. 2014 ; Vol. 2, No. 4. pp. 131-158.

Bibtex

@article{7ae575b1b89340d6ac4391c617ce10c1,
title = "Computational models of the NF-κB signalling pathway",
abstract = "In this review article, we discuss the current state of computational modelling of the nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-κB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-κB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-κB control.",
keywords = "NF-κB, computational biology, agent-based modelling, mathematical modelling, systems biology, signal transduction",
author = "Richard Williams and Jon Timmis and Qwarnstrom, {Eva E.}",
note = "Copyright 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license(http://creativecommons.org/licenses/by/4.0/).",
year = "2014",
month = sep,
day = "29",
doi = "10.3390/computation2040131",
language = "English",
volume = "2",
pages = "131--158",
journal = "Computation",
issn = "2079-3197",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "4",

}

RIS

TY - JOUR

T1 - Computational models of the NF-κB signalling pathway

AU - Williams, Richard

AU - Timmis, Jon

AU - Qwarnstrom, Eva E.

N1 - Copyright 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license(http://creativecommons.org/licenses/by/4.0/).

PY - 2014/9/29

Y1 - 2014/9/29

N2 - In this review article, we discuss the current state of computational modelling of the nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-κB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-κB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-κB control.

AB - In this review article, we discuss the current state of computational modelling of the nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-κB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-κB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-κB control.

KW - NF-κB

KW - computational biology

KW - agent-based modelling

KW - mathematical modelling

KW - systems biology

KW - signal transduction

U2 - 10.3390/computation2040131

DO - 10.3390/computation2040131

M3 - Journal article

VL - 2

SP - 131

EP - 158

JO - Computation

JF - Computation

SN - 2079-3197

IS - 4

ER -