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Controlled Bioactive Delivery Using Degradable Electroactive Polymers

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Controlled Bioactive Delivery Using Degradable Electroactive Polymers. / Ashton, Mark; Cooper, Patricia; Municoy, Sofia et al.
In: Biomacromolecules, Vol. 23, No. 7, 11.07.2022, p. 3031-3040.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Ashton, M, Cooper, P, Municoy, S, Desimone, M, Cheneler, D, Shnyder, S & Hardy, J 2022, 'Controlled Bioactive Delivery Using Degradable Electroactive Polymers', Biomacromolecules, vol. 23, no. 7, pp. 3031-3040. https://doi.org/10.1021/acs.biomac.2c00516

APA

Ashton, M., Cooper, P., Municoy, S., Desimone, M., Cheneler, D., Shnyder, S., & Hardy, J. (2022). Controlled Bioactive Delivery Using Degradable Electroactive Polymers. Biomacromolecules, 23(7), 3031-3040. https://doi.org/10.1021/acs.biomac.2c00516

Vancouver

Ashton M, Cooper P, Municoy S, Desimone M, Cheneler D, Shnyder S et al. Controlled Bioactive Delivery Using Degradable Electroactive Polymers. Biomacromolecules. 2022 Jul 11;23(7):3031-3040. Epub 2022 Jun 24. doi: 10.1021/acs.biomac.2c00516

Author

Ashton, Mark ; Cooper, Patricia ; Municoy, Sofia et al. / Controlled Bioactive Delivery Using Degradable Electroactive Polymers. In: Biomacromolecules. 2022 ; Vol. 23, No. 7. pp. 3031-3040.

Bibtex

@article{36e733c0f5c542f19c635373b0a38f72,
title = "Controlled Bioactive Delivery Using Degradable Electroactive Polymers",
abstract = "Biomaterials capable of precisely controlling the delivery of agrochemicals/biologics/drugs/fragrances have significant markets in the agriscience/healthcare industries. Here, we report the development of degradable electroactive polymers and their application for the controlled delivery of a clinically relevant drug (the anti-inflammatory dexamethasone phosphate, DMP). Electroactive copolymers composed of blocks of polycaprolactone (PCL) and naturally occurring electroactive pyrrole oligomers (e.g., bilirubin, biliverdin, and hemin) were prepared and solution-processed to produce films (optionally doped with DMP). A combination of in silico/in vitro/in vivo studies demonstrated the cytocompatibility of the polymers. The release of DMP in response to the application of an electrical stimulus was observed to be enhanced by ca. 10–30% relative to the passive release from nonstimulated samples in vitro. Such stimuli-responsive biomaterials have the potential for integration devices capable of delivering a variety of molecules for technical/medical applications.",
keywords = "drug delivery, stimuli-responsive, biomaterials",
author = "Mark Ashton and Patricia Cooper and Sofia Municoy and Martin Desimone and David Cheneler and Steven Shnyder and John Hardy",
year = "2022",
month = jul,
day = "11",
doi = "10.1021/acs.biomac.2c00516",
language = "English",
volume = "23",
pages = "3031--3040",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",
number = "7",

}

RIS

TY - JOUR

T1 - Controlled Bioactive Delivery Using Degradable Electroactive Polymers

AU - Ashton, Mark

AU - Cooper, Patricia

AU - Municoy, Sofia

AU - Desimone, Martin

AU - Cheneler, David

AU - Shnyder, Steven

AU - Hardy, John

PY - 2022/7/11

Y1 - 2022/7/11

N2 - Biomaterials capable of precisely controlling the delivery of agrochemicals/biologics/drugs/fragrances have significant markets in the agriscience/healthcare industries. Here, we report the development of degradable electroactive polymers and their application for the controlled delivery of a clinically relevant drug (the anti-inflammatory dexamethasone phosphate, DMP). Electroactive copolymers composed of blocks of polycaprolactone (PCL) and naturally occurring electroactive pyrrole oligomers (e.g., bilirubin, biliverdin, and hemin) were prepared and solution-processed to produce films (optionally doped with DMP). A combination of in silico/in vitro/in vivo studies demonstrated the cytocompatibility of the polymers. The release of DMP in response to the application of an electrical stimulus was observed to be enhanced by ca. 10–30% relative to the passive release from nonstimulated samples in vitro. Such stimuli-responsive biomaterials have the potential for integration devices capable of delivering a variety of molecules for technical/medical applications.

AB - Biomaterials capable of precisely controlling the delivery of agrochemicals/biologics/drugs/fragrances have significant markets in the agriscience/healthcare industries. Here, we report the development of degradable electroactive polymers and their application for the controlled delivery of a clinically relevant drug (the anti-inflammatory dexamethasone phosphate, DMP). Electroactive copolymers composed of blocks of polycaprolactone (PCL) and naturally occurring electroactive pyrrole oligomers (e.g., bilirubin, biliverdin, and hemin) were prepared and solution-processed to produce films (optionally doped with DMP). A combination of in silico/in vitro/in vivo studies demonstrated the cytocompatibility of the polymers. The release of DMP in response to the application of an electrical stimulus was observed to be enhanced by ca. 10–30% relative to the passive release from nonstimulated samples in vitro. Such stimuli-responsive biomaterials have the potential for integration devices capable of delivering a variety of molecules for technical/medical applications.

KW - drug delivery

KW - stimuli-responsive

KW - biomaterials

U2 - 10.1021/acs.biomac.2c00516

DO - 10.1021/acs.biomac.2c00516

M3 - Journal article

VL - 23

SP - 3031

EP - 3040

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

IS - 7

ER -