Home > Research > Publications & Outputs > Correlation between bacterial G+C content, geno...


Text available via DOI:

View graph of relations

Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages

Research output: Contribution to Journal/MagazineJournal articlepeer-review

<mark>Journal publication date</mark>04/2018
<mark>Journal</mark>Microbial Genomics
Issue number4
Number of pages8
Publication StatusPublished
Early online date10/04/18
<mark>Original language</mark>English


Based on complete bacterial genome sequence data, we demonstrate a correlation between bacterial chromosome length and the G+C content of the genome, with longer genomes having higher G+C contents. The correlation value decreases at shorter genome sizes, where there is a wider spread of G+C values. However, although significant (P<0.001), the correlation value (Pearson R=0.58) suggests that other factors also have a significant influence. A similar pattern was seen for plasmids; longer plasmids had higher G+C values, although the large number of shorter plasmids had a wide spread of G+C values. There was also a significant (P<0.0001) correlation between the G+C content of plasmids and the G+C content of their bacterial host. Conversely, the G+C content of bacteriophages tended to reduce with larger genome sizes, and although there was a correlation between host genome G+C content and that of the bacteriophage, it was not as strong as that seen between plasmids and their hosts.