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Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages

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Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages. / Almpanis, Apostolos; Swain, Martin; Gatherer, Derek et al.
In: Microbial Genomics, Vol. 2018, No. 4, 04.2018.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Almpanis, A, Swain, M, Gatherer, D & McEwan, N 2018, 'Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages', Microbial Genomics, vol. 2018, no. 4. https://doi.org/10.1099/mgen.0.000168

APA

Almpanis, A., Swain, M., Gatherer, D., & McEwan, N. (2018). Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages. Microbial Genomics, 2018(4). https://doi.org/10.1099/mgen.0.000168

Vancouver

Almpanis A, Swain M, Gatherer D, McEwan N. Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages. Microbial Genomics. 2018 Apr;2018(4). Epub 2018 Apr 10. doi: 10.1099/mgen.0.000168

Author

Almpanis, Apostolos ; Swain, Martin ; Gatherer, Derek et al. / Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages. In: Microbial Genomics. 2018 ; Vol. 2018, No. 4.

Bibtex

@article{e70e183dc2ff4b1d85413b2250d8d73e,
title = "Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages",
abstract = "Based on complete bacterial genome sequence data, we demonstrate a correlation between bacterial chromosome length and the G+C content of the genome, with longer genomes having higher G+C contents. The correlation value decreases at shorter genome sizes, where there is a wider spread of G+C values. However, although significant (P<0.001), the correlation value (Pearson R=0.58) suggests that other factors also have a significant influence. A similar pattern was seen for plasmids; longer plasmids had higher G+C values, although the large number of shorter plasmids had a wide spread of G+C values. There was also a significant (P<0.0001) correlation between the G+C content of plasmids and the G+C content of their bacterial host. Conversely, the G+C content of bacteriophages tended to reduce with larger genome sizes, and although there was a correlation between host genome G+C content and that of the bacteriophage, it was not as strong as that seen between plasmids and their hosts.",
keywords = "genome length, genome G+C content, bacteria, plasmids",
author = "Apostolos Almpanis and Martin Swain and Derek Gatherer and Neil McEwan",
year = "2018",
month = apr,
doi = "10.1099/mgen.0.000168",
language = "English",
volume = "2018",
journal = "Microbial Genomics",
issn = "2057-5858",
publisher = "Microbiology Society",
number = "4",

}

RIS

TY - JOUR

T1 - Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages

AU - Almpanis, Apostolos

AU - Swain, Martin

AU - Gatherer, Derek

AU - McEwan, Neil

PY - 2018/4

Y1 - 2018/4

N2 - Based on complete bacterial genome sequence data, we demonstrate a correlation between bacterial chromosome length and the G+C content of the genome, with longer genomes having higher G+C contents. The correlation value decreases at shorter genome sizes, where there is a wider spread of G+C values. However, although significant (P<0.001), the correlation value (Pearson R=0.58) suggests that other factors also have a significant influence. A similar pattern was seen for plasmids; longer plasmids had higher G+C values, although the large number of shorter plasmids had a wide spread of G+C values. There was also a significant (P<0.0001) correlation between the G+C content of plasmids and the G+C content of their bacterial host. Conversely, the G+C content of bacteriophages tended to reduce with larger genome sizes, and although there was a correlation between host genome G+C content and that of the bacteriophage, it was not as strong as that seen between plasmids and their hosts.

AB - Based on complete bacterial genome sequence data, we demonstrate a correlation between bacterial chromosome length and the G+C content of the genome, with longer genomes having higher G+C contents. The correlation value decreases at shorter genome sizes, where there is a wider spread of G+C values. However, although significant (P<0.001), the correlation value (Pearson R=0.58) suggests that other factors also have a significant influence. A similar pattern was seen for plasmids; longer plasmids had higher G+C values, although the large number of shorter plasmids had a wide spread of G+C values. There was also a significant (P<0.0001) correlation between the G+C content of plasmids and the G+C content of their bacterial host. Conversely, the G+C content of bacteriophages tended to reduce with larger genome sizes, and although there was a correlation between host genome G+C content and that of the bacteriophage, it was not as strong as that seen between plasmids and their hosts.

KW - genome length

KW - genome G+C content

KW - bacteria

KW - plasmids

U2 - 10.1099/mgen.0.000168

DO - 10.1099/mgen.0.000168

M3 - Journal article

C2 - 29633935

VL - 2018

JO - Microbial Genomics

JF - Microbial Genomics

SN - 2057-5858

IS - 4

ER -