Home > Research > Publications & Outputs > Cyclohexanehexol inhibitors of Aβ aggregation p...

Research

Links

Text available via DOI:

View graph of relations

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model. / McLaurin, Jo Anne; Kierstead, Meredith E.; Brown, Mary E. et al.
In: Nature Medicine, Vol. 12, No. 7, 01.07.2006, p. 801-808.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

McLaurin, JA, Kierstead, ME, Brown, ME, Hawkes, CA, Lambermon, MHL, Phinney, AL, Darabie, AA, Cousins, JE, French, JE, Lan, MF, Chen, F, Wong, SSN, Mount, HTJ, Fraser, PE, Westaway, D & George-Hyslop, PS 2006, 'Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model', Nature Medicine, vol. 12, no. 7, pp. 801-808. https://doi.org/10.1038/nm1423

APA

McLaurin, J. A., Kierstead, M. E., Brown, M. E., Hawkes, C. A., Lambermon, M. H. L., Phinney, A. L., Darabie, A. A., Cousins, J. E., French, J. E., Lan, M. F., Chen, F., Wong, S. S. N., Mount, H. T. J., Fraser, P. E., Westaway, D., & George-Hyslop, P. S. (2006). Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nature Medicine, 12(7), 801-808. https://doi.org/10.1038/nm1423

Vancouver

McLaurin JA, Kierstead ME, Brown ME, Hawkes CA, Lambermon MHL, Phinney AL et al. Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nature Medicine. 2006 Jul 1;12(7):801-808. Epub 2006 Jun 11. doi: 10.1038/nm1423

Author

McLaurin, Jo Anne ; Kierstead, Meredith E. ; Brown, Mary E. et al. / Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model. In: Nature Medicine. 2006 ; Vol. 12, No. 7. pp. 801-808.

Bibtex

@article{9553cdc7027f412c85535c8fce3a7da6,
title = "Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model",
abstract = "When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid β peptide (Aβ) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Aβ pathology and accelerated mortality. These therapeutic effects, which occur regardless of whether the compounds are given before or well after the onset of the Alzheimer disease-like phenotype, support the idea that the accumulation of Aβ oligomers has a central role in the pathogenesis of Alzheimer disease.",
author = "McLaurin, {Jo Anne} and Kierstead, {Meredith E.} and Brown, {Mary E.} and Hawkes, {Cheryl A.} and Lambermon, {Mark H.L.} and Phinney, {Amie L.} and Darabie, {Audrey A.} and Cousins, {Julian E.} and French, {Janet E.} and Lan, {Melissa F.} and Fusheng Chen and Wong, {Sydney S.N.} and Mount, {Howard T.J.} and Fraser, {Paul E.} and David Westaway and George-Hyslop, {Peter St}",
year = "2006",
month = jul,
day = "1",
doi = "10.1038/nm1423",
language = "English",
volume = "12",
pages = "801--808",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

AU - McLaurin, Jo Anne

AU - Kierstead, Meredith E.

AU - Brown, Mary E.

AU - Hawkes, Cheryl A.

AU - Lambermon, Mark H.L.

AU - Phinney, Amie L.

AU - Darabie, Audrey A.

AU - Cousins, Julian E.

AU - French, Janet E.

AU - Lan, Melissa F.

AU - Chen, Fusheng

AU - Wong, Sydney S.N.

AU - Mount, Howard T.J.

AU - Fraser, Paul E.

AU - Westaway, David

AU - George-Hyslop, Peter St

PY - 2006/7/1

Y1 - 2006/7/1

N2 - When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid β peptide (Aβ) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Aβ pathology and accelerated mortality. These therapeutic effects, which occur regardless of whether the compounds are given before or well after the onset of the Alzheimer disease-like phenotype, support the idea that the accumulation of Aβ oligomers has a central role in the pathogenesis of Alzheimer disease.

AB - When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid β peptide (Aβ) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Aβ pathology and accelerated mortality. These therapeutic effects, which occur regardless of whether the compounds are given before or well after the onset of the Alzheimer disease-like phenotype, support the idea that the accumulation of Aβ oligomers has a central role in the pathogenesis of Alzheimer disease.

U2 - 10.1038/nm1423

DO - 10.1038/nm1423

M3 - Journal article

C2 - 16767098

AN - SCOPUS:33745922350

VL - 12

SP - 801

EP - 808

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 7

ER -