Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Das ABC der medizinischen Statistik
T2 - Klinische Studien lesen und verstehen
AU - Labenz, J.
AU - Kunz, Cornelia U.
PY - 2010/4
Y1 - 2010/4
N2 - Clinical trials test hypotheses that are accepted or rejected according to a predetermined probability of error (level of significance). Significance does not however mean relevance. Good parameters of relevance are absolute risk reduction and based on this the calculation of the number of patients who need to be treated for one additional patient to benefit. The randomized controlled trial is the gold standard for comparative evaluation of effects. In the ideal scenario it is designed so that a difference established by statistical methods becomes probable. In non-inferiority studies care should be taken that no equivalence is shown but rather that the difference is not greater than a predefined margin of error for differences. Meta-analyses of studies with similar endpoints have the potential to improve the level of evidence. Since the findings of meta-analyses depend on the studies included, critical assessment of the results is essential.
AB - Clinical trials test hypotheses that are accepted or rejected according to a predetermined probability of error (level of significance). Significance does not however mean relevance. Good parameters of relevance are absolute risk reduction and based on this the calculation of the number of patients who need to be treated for one additional patient to benefit. The randomized controlled trial is the gold standard for comparative evaluation of effects. In the ideal scenario it is designed so that a difference established by statistical methods becomes probable. In non-inferiority studies care should be taken that no equivalence is shown but rather that the difference is not greater than a predefined margin of error for differences. Meta-analyses of studies with similar endpoints have the potential to improve the level of evidence. Since the findings of meta-analyses depend on the studies included, critical assessment of the results is essential.
KW - Clinical Trials as Topic
KW - Computer Simulation
KW - Data Interpretation, Statistical
KW - Meta-Analysis as Topic
KW - Models, Statistical
U2 - 10.1007/s00108-010-2581-x
DO - 10.1007/s00108-010-2581-x
M3 - Journal article
C2 - 20221576
VL - 51
SP - 489-99; quiz 500
JO - Der Internist
JF - Der Internist
SN - 1432-1289
IS - 4
ER -