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Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture

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Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture. / Bird, Nancy; Ormond, Louise; Awah, Paschal et al.
In: Science Advances, Vol. 9, No. 13, eabq2616, 29.03.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Bird, N, Ormond, L, Awah, P, Caldwell, EF, Connell, B, Elamin, M, Fadlelmola, FM, Matthew Fomine, FL, López, S, MacEachern, S, Moñino, Y, Morris, S, Näsänen-Gilmore, P, Nketsia V, NK, Veeramah, K, Weale, ME, Zeitlyn, D, Thomas, MG, Bradman, N & Hellenthal, G 2023, 'Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture', Science Advances, vol. 9, no. 13, eabq2616. https://doi.org/10.1126/sciadv.abq2616

APA

Bird, N., Ormond, L., Awah, P., Caldwell, E. F., Connell, B., Elamin, M., Fadlelmola, F. M., Matthew Fomine, F. L., López, S., MacEachern, S., Moñino, Y., Morris, S., Näsänen-Gilmore, P., Nketsia V, N. K., Veeramah, K., Weale, M. E., Zeitlyn, D., Thomas, M. G., Bradman, N., & Hellenthal, G. (2023). Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture. Science Advances, 9(13), Article eabq2616. https://doi.org/10.1126/sciadv.abq2616

Vancouver

Bird N, Ormond L, Awah P, Caldwell EF, Connell B, Elamin M et al. Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture. Science Advances. 2023 Mar 29;9(13):eabq2616. Epub 2023 Mar 29. doi: 10.1126/sciadv.abq2616

Author

Bird, Nancy ; Ormond, Louise ; Awah, Paschal et al. / Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture. In: Science Advances. 2023 ; Vol. 9, No. 13.

Bibtex

@article{c29ed64d5cb44a3eacf6c0da1a0d75cf,
title = "Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture",
abstract = "Previous studies have highlighted how African genomes have been shaped by a complex series of historical events. Despite this, genome-wide data have only been obtained from a small proportion of present-day ethnolinguistic groups. By analyzing new autosomal genetic variation data of 1333 individuals from over 150 ethnic groups from Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, we demonstrate a previously underappreciated fine-scale level of genetic structure within these countries, for example, correlating with historical polities in western Cameroon. By comparing genetic variation patterns among populations, we infer that many northern Cameroonian and Sudanese groups share genetic links with multiple geographically disparate populations, likely resulting from long-distance migrations. In Ghana and Nigeria, we infer signatures of intermixing dated to over 2000 years ago, corresponding to reports of environmental transformations possibly related to climate change. We also infer recent intermixing signals in multiple African populations, including Congolese, that likely relate to the expansions of Bantu language-speaking peoples.",
keywords = "Humans, Nigeria, Genetic Variation, Language, Ghana, Ethnicity - genetics, Chromosomes, Genetics, Population",
author = "Nancy Bird and Louise Ormond and Paschal Awah and Caldwell, {Elizabeth F} and Bruce Connell and Mohamed Elamin and Fadlelmola, {Faisal M} and {Matthew Fomine}, {Forka Leypey} and Saioa L{\'o}pez and Scott MacEachern and Yves Mo{\~n}ino and Sam Morris and Pieta N{\"a}s{\"a}nen-Gilmore and {Nketsia V}, {Nana Kobina} and Krishna Veeramah and Weale, {Michael E} and David Zeitlyn and Thomas, {Mark G} and Neil Bradman and Garrett Hellenthal",
year = "2023",
month = mar,
day = "29",
doi = "10.1126/sciadv.abq2616",
language = "English",
volume = "9",
journal = "Science Advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "13",

}

RIS

TY - JOUR

T1 - Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture

AU - Bird, Nancy

AU - Ormond, Louise

AU - Awah, Paschal

AU - Caldwell, Elizabeth F

AU - Connell, Bruce

AU - Elamin, Mohamed

AU - Fadlelmola, Faisal M

AU - Matthew Fomine, Forka Leypey

AU - López, Saioa

AU - MacEachern, Scott

AU - Moñino, Yves

AU - Morris, Sam

AU - Näsänen-Gilmore, Pieta

AU - Nketsia V, Nana Kobina

AU - Veeramah, Krishna

AU - Weale, Michael E

AU - Zeitlyn, David

AU - Thomas, Mark G

AU - Bradman, Neil

AU - Hellenthal, Garrett

PY - 2023/3/29

Y1 - 2023/3/29

N2 - Previous studies have highlighted how African genomes have been shaped by a complex series of historical events. Despite this, genome-wide data have only been obtained from a small proportion of present-day ethnolinguistic groups. By analyzing new autosomal genetic variation data of 1333 individuals from over 150 ethnic groups from Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, we demonstrate a previously underappreciated fine-scale level of genetic structure within these countries, for example, correlating with historical polities in western Cameroon. By comparing genetic variation patterns among populations, we infer that many northern Cameroonian and Sudanese groups share genetic links with multiple geographically disparate populations, likely resulting from long-distance migrations. In Ghana and Nigeria, we infer signatures of intermixing dated to over 2000 years ago, corresponding to reports of environmental transformations possibly related to climate change. We also infer recent intermixing signals in multiple African populations, including Congolese, that likely relate to the expansions of Bantu language-speaking peoples.

AB - Previous studies have highlighted how African genomes have been shaped by a complex series of historical events. Despite this, genome-wide data have only been obtained from a small proportion of present-day ethnolinguistic groups. By analyzing new autosomal genetic variation data of 1333 individuals from over 150 ethnic groups from Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, we demonstrate a previously underappreciated fine-scale level of genetic structure within these countries, for example, correlating with historical polities in western Cameroon. By comparing genetic variation patterns among populations, we infer that many northern Cameroonian and Sudanese groups share genetic links with multiple geographically disparate populations, likely resulting from long-distance migrations. In Ghana and Nigeria, we infer signatures of intermixing dated to over 2000 years ago, corresponding to reports of environmental transformations possibly related to climate change. We also infer recent intermixing signals in multiple African populations, including Congolese, that likely relate to the expansions of Bantu language-speaking peoples.

KW - Humans

KW - Nigeria

KW - Genetic Variation

KW - Language

KW - Ghana

KW - Ethnicity - genetics

KW - Chromosomes

KW - Genetics, Population

U2 - 10.1126/sciadv.abq2616

DO - 10.1126/sciadv.abq2616

M3 - Journal article

C2 - 36989356

VL - 9

JO - Science Advances

JF - Science Advances

SN - 2375-2548

IS - 13

M1 - eabq2616

ER -