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Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder

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  • Sarah Cohen-Woods
  • Daria Gaysina
  • Nick Craddock
  • Anne Farmer
  • Joanna Gray
  • Cerisse Gunasinghe
  • Farzana Hoda
  • Lisa Jones
  • Jo Knight
  • Ania Korszun
  • Michael J. Owen
  • Abram Sterne
  • Ian W. Craig
  • Peter McGuffin
<mark>Journal publication date</mark>15/04/2009
<mark>Journal</mark>Human Molecular Genetics
Issue number8
Number of pages6
Pages (from-to)1504-1509
Publication StatusPublished
Early online date30/01/09
<mark>Original language</mark>English


It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.