Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder

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Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. / Cohen-Woods, Sarah; Gaysina, Daria; Craddock, Nick et al.
In: Human Molecular Genetics, Vol. 18, No. 8, 15.04.2009, p. 1504-1509.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Cohen-Woods, S, Gaysina, D, Craddock, N, Farmer, A, Gray, J, Gunasinghe, C, Hoda, F, Jones, L, Knight, J, Korszun, A, Owen, MJ, Sterne, A, Craig, IW & McGuffin, P 2009, 'Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder', Human Molecular Genetics, vol. 18, no. 8, pp. 1504-1509. https://doi.org/10.1093/hmg/ddp051

APA

Cohen-Woods, S., Gaysina, D., Craddock, N., Farmer, A., Gray, J., Gunasinghe, C., Hoda, F., Jones, L., Knight, J., Korszun, A., Owen, M. J., Sterne, A., Craig, I. W., & McGuffin, P. (2009). Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. Human Molecular Genetics, 18(8), 1504-1509. https://doi.org/10.1093/hmg/ddp051

Vancouver

Cohen-Woods S, Gaysina D, Craddock N, Farmer A, Gray J, Gunasinghe C et al. Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. Human Molecular Genetics. 2009 Apr 15;18(8):1504-1509. Epub 2009 Jan 30. doi: 10.1093/hmg/ddp051

Author

Cohen-Woods, Sarah ; Gaysina, Daria ; Craddock, Nick et al. / Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. In: Human Molecular Genetics. 2009 ; Vol. 18, No. 8. pp. 1504-1509.

Bibtex

@article{e300b344c1c242439842b3fa1ddc0780,

title = "Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder",

abstract = "It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.",

keywords = "Case-Control Studies, Depressive Disorder, Female, Haplotypes, Humans, Male, Middle Aged, Receptor, Muscarinic M2, Recurrence",

author = "Sarah Cohen-Woods and Daria Gaysina and Nick Craddock and Anne Farmer and Joanna Gray and Cerisse Gunasinghe and Farzana Hoda and Lisa Jones and Jo Knight and Ania Korszun and Owen, {Michael J.} and Abram Sterne and Craig, {Ian W.} and Peter McGuffin",

year = "2009",

month = apr,

day = "15",

doi = "10.1093/hmg/ddp051",

language = "English",

volume = "18",

pages = "1504--1509",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "8",

}

RIS

TY - JOUR

T1 - Depression Case Control (DeCC) study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder

AU - Cohen-Woods, Sarah

AU - Gaysina, Daria

AU - Craddock, Nick

AU - Farmer, Anne

AU - Gray, Joanna

AU - Gunasinghe, Cerisse

AU - Hoda, Farzana

AU - Jones, Lisa

AU - Knight, Jo

AU - Korszun, Ania

AU - Owen, Michael J.

AU - Sterne, Abram

AU - Craig, Ian W.

AU - McGuffin, Peter

PY - 2009/4/15

Y1 - 2009/4/15

N2 - It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.

AB - It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.

KW - Case-Control Studies

KW - Depressive Disorder

KW - Female

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Receptor, Muscarinic M2

KW - Recurrence

U2 - 10.1093/hmg/ddp051

DO - 10.1093/hmg/ddp051

M3 - Journal article

C2 - 19181679

VL - 18

SP - 1504

EP - 1509

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 8

ER -

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