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Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City

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Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City. / Yuan, Xiaojie; Fu, Ting; Xiao, Lixin et al.
In: Front. Immunol., Vol. 13, 1025654, 11.10.2022.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Yuan, X, Fu, T, Xiao, L, He, Z, Ji, Z, Seery, S, Zhang, W, Ye, Y, Zhou, H, Kong, X, Zhang, S, Zhou, Q, Lin, Y, Jia, W, Liang, C, Tang, H, Wang, F, Zhang, W & Shao, Z 2022, 'Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City', Front. Immunol., vol. 13, 1025654. https://doi.org/10.3389/fimmu.2022.1025654

APA

Yuan, X., Fu, T., Xiao, L., He, Z., Ji, Z., Seery, S., Zhang, W., Ye, Y., Zhou, H., Kong, X., Zhang, S., Zhou, Q., Lin, Y., Jia, W., Liang, C., Tang, H., Wang, F., Zhang, W., & Shao, Z. (2022). Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City. Front. Immunol., 13, Article 1025654. https://doi.org/10.3389/fimmu.2022.1025654

Vancouver

Yuan X, Fu T, Xiao L, He Z, Ji Z, Seery S et al. Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City. Front. Immunol. 2022 Oct 11;13:1025654. doi: 10.3389/fimmu.2022.1025654

Author

Yuan, Xiaojie ; Fu, Ting ; Xiao, Lixin et al. / Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City. In: Front. Immunol. 2022 ; Vol. 13.

Bibtex

@article{516c138abae14c0d954373050ab267dd,
title = "Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City",
abstract = "Background: Hepatitis B surface antigen (HBsAg) loss is considered a functional cure for chronic hepatitis B (CHB), however, several factors influence HBsAg loss. Methods: 29 CHB patients who had achieved HBsAg loss, were selected and 58 CHB patients with persistent HBsAg were matched, according to gender and age (+/- 3 years). Logistic regression and restricted cubic spline (RCS) modelling were performed. Results: Multivariate-adjusted logistic regression, based on stepwise selection, showed that baseline HBsAg levels negatively correlated with HBsAg loss (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.98-0.99). Interferon treatment positively related with HBsAg loss (OR = 7.99, 95%CI = 1.62-44.88). After adjusting for age, HBsAg level, ALT level, HBeAg status and interferon treatment, MMP-1 (OR = 0.66, 95%CI = 0.44-0.97), CXCL9 (OR = 0.96, 95%CI = 0.93-0.99) and TNF-R1 (OR = 0.97, 95%CI = 0.94-0.99) baseline levels all negatively correlated with HBsAg loss. Our multivariate-adjusted RCS model showed that baseline CXCL10 was associated with HBsAg loss although the relationship was “U-shaped”. Conclusions: Cytokines such as MMP-1, CXCL9, CXCL10 and TNF-R1 are important factors which influence HBsAg loss. It may be possible to develop a nomogram which intercalates these factors; however, further research should consider immune processes involved in HBsAg loss.",
keywords = "Immunology, HBsAg, interferon, chemokine, MMP-1, TNF-R1",
author = "Xiaojie Yuan and Ting Fu and Lixin Xiao and Zhen He and Zhaohua Ji and Samuel Seery and Wenhua Zhang and Yancheng Ye and Haowei Zhou and Xiangyu Kong and Shuyuan Zhang and Qi Zhou and Yulian Lin and Wenling Jia and Chunhui Liang and Haitao Tang and Fengmei Wang and Weilu Zhang and Zhongjun Shao",
year = "2022",
month = oct,
day = "11",
doi = "10.3389/fimmu.2022.1025654",
language = "English",
volume = "13",
journal = "Front. Immunol.",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei City

AU - Yuan, Xiaojie

AU - Fu, Ting

AU - Xiao, Lixin

AU - He, Zhen

AU - Ji, Zhaohua

AU - Seery, Samuel

AU - Zhang, Wenhua

AU - Ye, Yancheng

AU - Zhou, Haowei

AU - Kong, Xiangyu

AU - Zhang, Shuyuan

AU - Zhou, Qi

AU - Lin, Yulian

AU - Jia, Wenling

AU - Liang, Chunhui

AU - Tang, Haitao

AU - Wang, Fengmei

AU - Zhang, Weilu

AU - Shao, Zhongjun

PY - 2022/10/11

Y1 - 2022/10/11

N2 - Background: Hepatitis B surface antigen (HBsAg) loss is considered a functional cure for chronic hepatitis B (CHB), however, several factors influence HBsAg loss. Methods: 29 CHB patients who had achieved HBsAg loss, were selected and 58 CHB patients with persistent HBsAg were matched, according to gender and age (+/- 3 years). Logistic regression and restricted cubic spline (RCS) modelling were performed. Results: Multivariate-adjusted logistic regression, based on stepwise selection, showed that baseline HBsAg levels negatively correlated with HBsAg loss (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.98-0.99). Interferon treatment positively related with HBsAg loss (OR = 7.99, 95%CI = 1.62-44.88). After adjusting for age, HBsAg level, ALT level, HBeAg status and interferon treatment, MMP-1 (OR = 0.66, 95%CI = 0.44-0.97), CXCL9 (OR = 0.96, 95%CI = 0.93-0.99) and TNF-R1 (OR = 0.97, 95%CI = 0.94-0.99) baseline levels all negatively correlated with HBsAg loss. Our multivariate-adjusted RCS model showed that baseline CXCL10 was associated with HBsAg loss although the relationship was “U-shaped”. Conclusions: Cytokines such as MMP-1, CXCL9, CXCL10 and TNF-R1 are important factors which influence HBsAg loss. It may be possible to develop a nomogram which intercalates these factors; however, further research should consider immune processes involved in HBsAg loss.

AB - Background: Hepatitis B surface antigen (HBsAg) loss is considered a functional cure for chronic hepatitis B (CHB), however, several factors influence HBsAg loss. Methods: 29 CHB patients who had achieved HBsAg loss, were selected and 58 CHB patients with persistent HBsAg were matched, according to gender and age (+/- 3 years). Logistic regression and restricted cubic spline (RCS) modelling were performed. Results: Multivariate-adjusted logistic regression, based on stepwise selection, showed that baseline HBsAg levels negatively correlated with HBsAg loss (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.98-0.99). Interferon treatment positively related with HBsAg loss (OR = 7.99, 95%CI = 1.62-44.88). After adjusting for age, HBsAg level, ALT level, HBeAg status and interferon treatment, MMP-1 (OR = 0.66, 95%CI = 0.44-0.97), CXCL9 (OR = 0.96, 95%CI = 0.93-0.99) and TNF-R1 (OR = 0.97, 95%CI = 0.94-0.99) baseline levels all negatively correlated with HBsAg loss. Our multivariate-adjusted RCS model showed that baseline CXCL10 was associated with HBsAg loss although the relationship was “U-shaped”. Conclusions: Cytokines such as MMP-1, CXCL9, CXCL10 and TNF-R1 are important factors which influence HBsAg loss. It may be possible to develop a nomogram which intercalates these factors; however, further research should consider immune processes involved in HBsAg loss.

KW - Immunology

KW - HBsAg

KW - interferon

KW - chemokine

KW - MMP-1

KW - TNF-R1

U2 - 10.3389/fimmu.2022.1025654

DO - 10.3389/fimmu.2022.1025654

M3 - Journal article

VL - 13

JO - Front. Immunol.

JF - Front. Immunol.

SN - 1664-3224

M1 - 1025654

ER -