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Design of a clustered observational study to predict emergency admissions in the elderly : statistical reasoning in clinical practice.

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Design of a clustered observational study to predict emergency admissions in the elderly : statistical reasoning in clinical practice. / Lancaster, Gillian A.; Chellaswamy, Hannah; Taylor, Steve et al.
In: Journal of Evaluation in Clinical Practice, Vol. 13, No. 2, 04.2007, p. 169-178.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lancaster, GA, Chellaswamy, H, Taylor, S, Lyon, D & Dowrick, C 2007, 'Design of a clustered observational study to predict emergency admissions in the elderly : statistical reasoning in clinical practice.', Journal of Evaluation in Clinical Practice, vol. 13, no. 2, pp. 169-178. https://doi.org/10.1111/j.1365-2753.2006.00663.x

APA

Lancaster, G. A., Chellaswamy, H., Taylor, S., Lyon, D., & Dowrick, C. (2007). Design of a clustered observational study to predict emergency admissions in the elderly : statistical reasoning in clinical practice. Journal of Evaluation in Clinical Practice, 13(2), 169-178. https://doi.org/10.1111/j.1365-2753.2006.00663.x

Vancouver

Lancaster GA, Chellaswamy H, Taylor S, Lyon D, Dowrick C. Design of a clustered observational study to predict emergency admissions in the elderly : statistical reasoning in clinical practice. Journal of Evaluation in Clinical Practice. 2007 Apr;13(2):169-178. doi: 10.1111/j.1365-2753.2006.00663.x

Author

Lancaster, Gillian A. ; Chellaswamy, Hannah ; Taylor, Steve et al. / Design of a clustered observational study to predict emergency admissions in the elderly : statistical reasoning in clinical practice. In: Journal of Evaluation in Clinical Practice. 2007 ; Vol. 13, No. 2. pp. 169-178.

Bibtex

@article{2d0c4e7550454a5d9a8ee4ce7326a10c,
title = "Design of a clustered observational study to predict emergency admissions in the elderly : statistical reasoning in clinical practice.",
abstract = "Objective To describe the statistical design issues and practical considerations that had to be addressed in setting up a clustered observational study of emergency admission to hospital of elderly people. Study design and setting Clustered observational study (sample survey) of elderly people registered with 18 general practices in Halton Primary Care Trust in the north-west of England. Results The statistical design features that warranted particular attention were sample size determination, intra-class correlation, sampling and recruitment, bias and confounding. Pragmatic decisions based on derived scenarios of different design effects are discussed. A pilot study was carried out in one practice. From the remaining practices, a total of 4000 people were sampled, stratified by gender. The average cluster size was 200 and the intra-class correlation coefficient for the emergency admission outcome was 0.00034, 95% confidence interval (0–0.008). Conclusion Studies that involve sampling from clusters of people are common in a wide range of healthcare settings. The clustering adds an extra level of complexity to the study design. This study provides an empirical illustration of the importance of statistical as well as clinical reasoning in study design in clinical practice.",
keywords = "clustered observational study, intra-class correlation coefficient, multilevel logistic regression, sample size",
author = "Lancaster, {Gillian A.} and Hannah Chellaswamy and Steve Taylor and David Lyon and Chris Dowrick",
year = "2007",
month = apr,
doi = "10.1111/j.1365-2753.2006.00663.x",
language = "English",
volume = "13",
pages = "169--178",
journal = "Journal of Evaluation in Clinical Practice",
issn = "1356-1294",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Design of a clustered observational study to predict emergency admissions in the elderly : statistical reasoning in clinical practice.

AU - Lancaster, Gillian A.

AU - Chellaswamy, Hannah

AU - Taylor, Steve

AU - Lyon, David

AU - Dowrick, Chris

PY - 2007/4

Y1 - 2007/4

N2 - Objective To describe the statistical design issues and practical considerations that had to be addressed in setting up a clustered observational study of emergency admission to hospital of elderly people. Study design and setting Clustered observational study (sample survey) of elderly people registered with 18 general practices in Halton Primary Care Trust in the north-west of England. Results The statistical design features that warranted particular attention were sample size determination, intra-class correlation, sampling and recruitment, bias and confounding. Pragmatic decisions based on derived scenarios of different design effects are discussed. A pilot study was carried out in one practice. From the remaining practices, a total of 4000 people were sampled, stratified by gender. The average cluster size was 200 and the intra-class correlation coefficient for the emergency admission outcome was 0.00034, 95% confidence interval (0–0.008). Conclusion Studies that involve sampling from clusters of people are common in a wide range of healthcare settings. The clustering adds an extra level of complexity to the study design. This study provides an empirical illustration of the importance of statistical as well as clinical reasoning in study design in clinical practice.

AB - Objective To describe the statistical design issues and practical considerations that had to be addressed in setting up a clustered observational study of emergency admission to hospital of elderly people. Study design and setting Clustered observational study (sample survey) of elderly people registered with 18 general practices in Halton Primary Care Trust in the north-west of England. Results The statistical design features that warranted particular attention were sample size determination, intra-class correlation, sampling and recruitment, bias and confounding. Pragmatic decisions based on derived scenarios of different design effects are discussed. A pilot study was carried out in one practice. From the remaining practices, a total of 4000 people were sampled, stratified by gender. The average cluster size was 200 and the intra-class correlation coefficient for the emergency admission outcome was 0.00034, 95% confidence interval (0–0.008). Conclusion Studies that involve sampling from clusters of people are common in a wide range of healthcare settings. The clustering adds an extra level of complexity to the study design. This study provides an empirical illustration of the importance of statistical as well as clinical reasoning in study design in clinical practice.

KW - clustered observational study

KW - intra-class correlation coefficient

KW - multilevel logistic regression

KW - sample size

U2 - 10.1111/j.1365-2753.2006.00663.x

DO - 10.1111/j.1365-2753.2006.00663.x

M3 - Journal article

VL - 13

SP - 169

EP - 178

JO - Journal of Evaluation in Clinical Practice

JF - Journal of Evaluation in Clinical Practice

SN - 1356-1294

IS - 2

ER -